Agents and Actions

, Volume 36, Supplement 2, pp C394–C397 | Cite as

Histamine tele-methylhistamine ratios in rat blood as a function of time after i.v. injection of compound 48/80 or histamine

  • T. Irman-Florjanc
  • F. Erjavec
Plenary Lecture Histamine Metabolism


The pharmacokinetic characteristics of histamine (Hi) and tele-methylhistamine (MeHi) were studied by following their concentrations in rat blood by HPLC after i.v. injection of Hi or compound 48/80. Both injected substances caused a significant elevation of Hi as well as MeHi levels in the blood. The elimination curves for Hi showed two phases and significant differences depending on the injected substance. Following Hi injection, blood MeHi reached a maximum within 10–30 min and returned to baseline after about 50 min. (Hi reached a maximum after 15 min.) Following injection of compound 48/80, Hi reached a maximum at 10–15 min and MeHi at 40–45 min. It can be suggested that the significance of Hi or MeHi data in the circulating blood depends on the time which elapses from the maximal Hi concentration in the blood.


Histamine Significant Elevation Pharmacokinetic Characteristic Elimination Curve 
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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • T. Irman-Florjanc
    • 1
  • F. Erjavec
    • 1
  1. 1.Department of Pharmacology, Medical FacultyUniversity of LjubljanaLjubljanaSlovenia

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