Agents and Actions

, Volume 36, Supplement 2, pp C384–C386 | Cite as

Histamine level and transglutaminase activity may provide indication of the development of spontaneous mammary tumor in C3H mice

  • C. Maśliński
  • D. Kierska
Plenary Lecture Effect of Histmine on Cell Growth and Angiogenesis


Histamine (HA) concentrations and HA metabolizing enzyme activities were measured in macroscopically unchanged mammary glands and in tumor tissue of C3H mice carrying spontaneous mammary tumor as well as im mammary glands of control subjects matched for age.

The great fall in HA level and the enzyme activities in tumor tissue was confirmed. In host mammary glands which showed no current evidence of neoplasm, consistently lower than normal HA concentrations and elevated transglutaminase (TG) activity were found, It is suggested, therefore, that HA level and TG activity may provide an early indication of the development of spontaneous mammary tumor.


Enzyme Activity Control Subject Tumor Tissue Histamine Mammary Gland 
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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • C. Maśliński
    • 1
  • D. Kierska
    • 1
  1. 1.Department of Biogenic Amines of Polish Academy of SciencesLodzPoland

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