Agents and Actions

, Volume 36, Supplement 2, pp C365–C367 | Cite as

Effect of gastric stimulants on histamine release and circulatory responses

  • W. K. Man
  • S. K. Li
  • R. T. Mathie
  • J. Spencer
Plenary Lecture Histamine and the Gastrointestinal Tract

Abstract

The effects of pentagastrin (6 μg/kg/h) or insulin (0.15 U/kg/h) on histamine release and blood circulation in nine anaesthetized dogs were studied by measuring (1) plasma histamine concentrations in the iliac artery, iliac vein, hepatic vein and portal vein, (2) the corresponding blood pressures, and (3) blood flow in the hepatic artery and the portal vein. In the portal vein, pentagastrin induced an overall 204% rise (p<0.01) in plasma histamine and a 28% rise (p<0.01) in blood flow while other measurements did not change significantly. Insulin did not induce similar rises. Three patients with duodenal ulcer (DU) undergoing proximal gastric vagotomy (PGV) were given pentagastrin (6 μg/kg) by bolus injection. Plasma histamine concentrations in the gastric veins draining the oxyntic cell area rose by 68%, 15 min after injection. Thus, specific histamine release may act as a mediator for pentagastrin-stimulated gastric acid secretion and as a vasodilator to facilitate gastric circulation. Insulin did not promote histamine release in the present study.

Keywords

Histamine Portal Vein Duodenal Ulcer Iliac Artery Hepatic Vein 

References

  1. [1]
    R. T. Mathie, J. B. Desai and K. M. Taylor,The effect of normothermic cardiopulmonary bypass on hepatic blood flow in the dog. Perfusion1, 245–253 (1986).Google Scholar
  2. [2]
    C. P. Hansen, W. K. Man, P. Kirkegaard, S. L. Jensen and S. BoesbyChanges in plasma histamine during orthotopic liver transplantation in the pig. Agents and Actions23, 348–350 (1988).PubMedGoogle Scholar
  3. [3]
    J. W. Black and N. P. Shankley,How does gastrin act to stimulate oxyntic cell secretion? Trends Pharmacol. Sci.8, 486–490 (1987).CrossRefGoogle Scholar
  4. [4]
    W. K. Man, J. H. Saunders, C. Ingoldby and J. Spencer,Effect of pentagastrin on histamine out put from the stomach in patients with duodenal ulcer. Gut22, 916–922 (1981).PubMedGoogle Scholar
  5. [5]
    W. K. Man, C. J. H. Ingoldby and J. Spencer,Is pentagastrinstimulated secretion mediated by histamine? Gut25, 965–970 (1984).PubMedGoogle Scholar
  6. [6]
    C. J. H. Ingoldby, W. K. Man and J. Spencer,Gastric histamine release during insulin and pentagastrin infusion in patients with duodenal ulcer. Am J. Gastroenterol.79, 16–20 (1984).PubMedGoogle Scholar
  7. [7]
    W. Lorenz, J. V. Parkin, H. Rohde, H. Barth, H. Troidl, K. Thon, E. Hinterlang, D. Weber, R. Albrecht and H. Roher,Histamine in gastric secretory disorder: the relevance of the mucosal histamine content and the origin of histamine in gastric aspirate, In:Gastric secretion, basic and clinical aspects (Ed. S. J. Konturek and W. Domschke) pp. 29–51, Georg Thieme Verlag, Stuttgart 1981.Google Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • W. K. Man
    • 1
  • S. K. Li
    • 1
  • R. T. Mathie
    • 1
  • J. Spencer
    • 1
  1. 1.Department of SurgeryRoyal Postgraduate Medical SchoolLondonUK

Personalised recommendations