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, Volume 36, Supplement 2, pp C336–C338 | Cite as

Sexual dimorphism modulates brain histamine functions at multiple sites

  • M. Blengio
  • C. Ferretti
  • P. Ghi
  • T. Adage
  • P. Portaleone
Plenary Lecture Histamine and the Central Nervous System


Sexual dimorphism has been demonstrated in rat brain and the ovarian steroids affect H1 and H2 histaminergic binding sites as demonstrated with [3H]-mepyramine and [3H]-histamine, respectively. The evaluation of histamine release, related to the presynaptic H3 receptors, from cortical slice preparations reveals hyposensitive releasing activity in the female rat compared to the male, both after KCl-induced histamine release and after inhibition of histamine release by (R)α-methylhistamine (H3 selective agonist). Therefore, we may suggest a global hyposensitivity of the histaminergic neural system in female rats under the modulation of ovarian sexual steroids.


Steroid Histamine Sexual Dimorphism Sexual Steroid Multiple Site 
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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • M. Blengio
    • 1
  • C. Ferretti
    • 1
  • P. Ghi
    • 1
  • T. Adage
    • 1
  • P. Portaleone
    • 1
  1. 1.Institute of Pharmacology and Expt. Therapy, School of MedicineUniversity of TorinoTorinoItaly

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