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, Volume 36, Supplement 2, pp C336–C338 | Cite as

Sexual dimorphism modulates brain histamine functions at multiple sites

  • M. Blengio
  • C. Ferretti
  • P. Ghi
  • T. Adage
  • P. Portaleone
Plenary Lecture Histamine and the Central Nervous System
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Abstract

Sexual dimorphism has been demonstrated in rat brain and the ovarian steroids affect H1 and H2 histaminergic binding sites as demonstrated with [3H]-mepyramine and [3H]-histamine, respectively. The evaluation of histamine release, related to the presynaptic H3 receptors, from cortical slice preparations reveals hyposensitive releasing activity in the female rat compared to the male, both after KCl-induced histamine release and after inhibition of histamine release by (R)α-methylhistamine (H3 selective agonist). Therefore, we may suggest a global hyposensitivity of the histaminergic neural system in female rats under the modulation of ovarian sexual steroids.

Keywords

Steroid Histamine Sexual Dimorphism Sexual Steroid Multiple Site 

References

  1. [1]
    J.-C. Schwartz, J.-M. Arrang and M. Garbarg,Three classes of histamine receptors in brain. Trends Pharmacol. Sci.7, 24–28 (1986).CrossRefGoogle Scholar
  2. [2]
    S. J. Hill,Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol. Rev.42, 45–83 (1990).PubMedGoogle Scholar
  3. [3]
    P. Ghi, C. Ferretti, M. L. Lupi, M. Blengio and P. Portaleone,H1 and H2 receptors of rat brain are affected by hormones and stress. InModulation of Central and Peripheral Transmitter Function. Symposia in Neuroscience, Vol. 3 (Eds. G. Biggio, P. F. Spano and G. L. Gessa), pp. 497–501, Liviana Press, Padova 1986.Google Scholar
  4. [4]
    P. Ghi, C. Ferretti, M. L. Lupi, M. Blengio and P. Portaleone,Sexual dimorphism in [3 H]-histamine binding sites of rat cerebral cortex. Pharmacol. Res.23, 187–193 (1991).PubMedGoogle Scholar
  5. [5]
    A. M. Seltzer and A. O. Donoso,Effects of ovariectomy and ovarian steroids on binding of [3 H]-mepyramine, an H 1-histamine antagonist, in rat hypothalamus. Brain Res. Bull23, 183–186 (1989).CrossRefPubMedGoogle Scholar
  6. [6]
    J.-M. Arrang, M. Garbarg and J.-C. Schwartz,Autoinhibition of brain histamine release mediated by a novel class (H-3) of histamine receptor. Nature302, 832–837 (1983).CrossRefPubMedGoogle Scholar
  7. [7]
    S. J. Hill and R. M.Straw α 2-adrenoceptor-mediated inhibition of histamine release from rat cerebral cortical slices. Br. J. Pharmacol.95, 1213–1219 (1988).PubMedGoogle Scholar
  8. [8]
    A. O. Donoso and E. O. Alvarez,Brain histamine as neuroendocrine transmitter. Trends Pharmacol. Sci.5, 98–100 (1984).CrossRefGoogle Scholar
  9. [9]
    L. B. Hough,Cellular localization and possible functions for brain histamine: recent progress. Progr. Neurobiol.30, 469–505 (1988).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • M. Blengio
    • 1
  • C. Ferretti
    • 1
  • P. Ghi
    • 1
  • T. Adage
    • 1
  • P. Portaleone
    • 1
  1. 1.Institute of Pharmacology and Expt. Therapy, School of MedicineUniversity of TorinoTorinoItaly

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