Sexual dimorphism modulates brain histamine functions at multiple sites
- 15 Downloads
Sexual dimorphism has been demonstrated in rat brain and the ovarian steroids affect H1 and H2 histaminergic binding sites as demonstrated with [3H]-mepyramine and [3H]-histamine, respectively. The evaluation of histamine release, related to the presynaptic H3 receptors, from cortical slice preparations reveals hyposensitive releasing activity in the female rat compared to the male, both after KCl-induced histamine release and after inhibition of histamine release by (R)α-methylhistamine (H3 selective agonist). Therefore, we may suggest a global hyposensitivity of the histaminergic neural system in female rats under the modulation of ovarian sexual steroids.
KeywordsSteroid Histamine Sexual Dimorphism Sexual Steroid Multiple Site
- P. Ghi, C. Ferretti, M. L. Lupi, M. Blengio and P. Portaleone,H1 and H2 receptors of rat brain are affected by hormones and stress. InModulation of Central and Peripheral Transmitter Function. Symposia in Neuroscience, Vol. 3 (Eds. G. Biggio, P. F. Spano and G. L. Gessa), pp. 497–501, Liviana Press, Padova 1986.Google Scholar