The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4 M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6 M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4 M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4 M. Cadmium increased the histamine release in adenoidal cells at 10−4 M but in cutaneous cells only the stimulated release (10−8–10−5 M) was affected. Bismuth inhibited the histamine release at 10−4 M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
M. Wieczorek and H. Behrendt,Wirkung von Kadmium und Blei auf Mediatorzellen allergischer Reaktionen. Allergologie12, 158–160 (1989).
W. Schmutzler, K. Delmich, D. Eichelberg, St. Glück, T. Greven, H. Jürgensen, K. Riesener, G. Risse, P. Pult,The human adenoidal mast cell. Susceptibility to different secretagogues and secretion inhibitors. Int. Archs. Allergy appl. Immun.77, 177–178 (1985).
R. Benyon, M. A. Lowman and M. K. Church,Human skin mast cells: their dispersion, purification and secretory characterization. J. Immunol.138, 861–867 (1987).
M. A. Beaven, S. Jacobsen and Z. Horakova,Modification of the enzymic isotopic assay of histamine and its application to measurement of histamine in tissue, serum and urine. Clin. Chem. Acta37, 91–103 (1972).
C. D. Klassen,Lead InThe pharmacological basis of therapeutics, (Ed. A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor) pp. 1592–1598, Pergamon, New York 1990.
A. Laschi-Loquerie, J. Descotes, P. Tachon, and J. C. Evreux,Influence of lead on the hypersensitivity experimental study. J. Immunopharmacol.6, 87–93 (1984).
D. Sutoo, K. Akiyama and S. Imamiya,A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system. Arch. Toxicol.64, 161–164 (1990).
Y. Suzuki, S.-H. Chao, J. R. Zysk and W. Y. Cheung,Stimulation of calmodulin by cadmium ion. Arch. Toxicol.57, 205–211 (1985).
S. Bent, U. Braam, W. Schmutzler,Effects of calmodulin antagonists on human adenoidal mast cells. Agents and Actions30, 121–124 (1990).
N. Chakravarty,Histamine secretion from permeabilized mast cells by calcium. Life Sci.39, 1549–1554 (1986).
About this article
Cite this article
Bent, S., Göttsch, C., Braam, U. et al. The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells. Agents and Actions 36, C321–C324 (1992). https://doi.org/10.1007/BF01997363
- Heavy Metal
- Mast Cell