The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells
- 55 Downloads
The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4M. Cadmium increased the histamine release in adenoidal cells at 10−4M but in cutaneous cells only the stimulated release (10−8–10−5M) was affected. Bismuth inhibited the histamine release at 10−4M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.
- M. Wieczorek and H. Behrendt,Wirkung von Kadmium und Blei auf Mediatorzellen allergischer Reaktionen. Allergologie12, 158–160 (1989).Google Scholar
- W. Schmutzler, K. Delmich, D. Eichelberg, St. Glück, T. Greven, H. Jürgensen, K. Riesener, G. Risse, P. Pult,The human adenoidal mast cell. Susceptibility to different secretagogues and secretion inhibitors. Int. Archs. Allergy appl. Immun.77, 177–178 (1985).Google Scholar
- C. D. Klassen,Lead InThe pharmacological basis of therapeutics, (Ed. A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor) pp. 1592–1598, Pergamon, New York 1990.Google Scholar