Agents and Actions

, Volume 36, Supplement 2, pp C321–C324

The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells

  • S. Bent
  • C. Göttsch
  • U. Braam
  • W. Schmutzler
Plenary Lecture Histamine Release

Abstract

The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4M. Cadmium increased the histamine release in adenoidal cells at 10−4M but in cutaneous cells only the stimulated release (10−8–10−5M) was affected. Bismuth inhibited the histamine release at 10−4M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.

References

  1. [1]
    M. Wieczorek and H. Behrendt,Wirkung von Kadmium und Blei auf Mediatorzellen allergischer Reaktionen. Allergologie12, 158–160 (1989).Google Scholar
  2. [2]
    W. Schmutzler, K. Delmich, D. Eichelberg, St. Glück, T. Greven, H. Jürgensen, K. Riesener, G. Risse, P. Pult,The human adenoidal mast cell. Susceptibility to different secretagogues and secretion inhibitors. Int. Archs. Allergy appl. Immun.77, 177–178 (1985).Google Scholar
  3. [3]
    R. Benyon, M. A. Lowman and M. K. Church,Human skin mast cells: their dispersion, purification and secretory characterization. J. Immunol.138, 861–867 (1987).PubMedGoogle Scholar
  4. [4]
    M. A. Beaven, S. Jacobsen and Z. Horakova,Modification of the enzymic isotopic assay of histamine and its application to measurement of histamine in tissue, serum and urine. Clin. Chem. Acta37, 91–103 (1972).CrossRefGoogle Scholar
  5. [5]
    C. D. Klassen,Lead InThe pharmacological basis of therapeutics, (Ed. A. Goodman Gilman, T. W. Rall, A. S. Nies and P. Taylor) pp. 1592–1598, Pergamon, New York 1990.Google Scholar
  6. [6]
    A. Laschi-Loquerie, J. Descotes, P. Tachon, and J. C. Evreux,Influence of lead on the hypersensitivity experimental study. J. Immunopharmacol.6, 87–93 (1984).CrossRefPubMedGoogle Scholar
  7. [7]
    D. Sutoo, K. Akiyama and S. Imamiya,A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system. Arch. Toxicol.64, 161–164 (1990).CrossRefPubMedGoogle Scholar
  8. [8]
    Y. Suzuki, S.-H. Chao, J. R. Zysk and W. Y. Cheung,Stimulation of calmodulin by cadmium ion. Arch. Toxicol.57, 205–211 (1985).CrossRefPubMedGoogle Scholar
  9. [9]
    S. Bent, U. Braam, W. Schmutzler,Effects of calmodulin antagonists on human adenoidal mast cells. Agents and Actions30, 121–124 (1990).CrossRefGoogle Scholar
  10. [10]
    N. Chakravarty,Histamine secretion from permeabilized mast cells by calcium. Life Sci.39, 1549–1554 (1986).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • S. Bent
    • 1
  • C. Göttsch
    • 1
  • U. Braam
    • 1
  • W. Schmutzler
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieMedizinische Fakultät der RWTH AachenAachenFRG

Personalised recommendations