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The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells

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  • Histamine Release
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Abstract

The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4 M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6 M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4 M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4 M. Cadmium increased the histamine release in adenoidal cells at 10−4 M but in cutaneous cells only the stimulated release (10−8–10−5 M) was affected. Bismuth inhibited the histamine release at 10−4 M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der RWTH Aachen, Wendlingweg 2, 5100, Aachen, FRG

    S. Bent, C. Göttsch, U. Braam & W. Schmutzler

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  1. S. Bent
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  2. C. Göttsch
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  3. U. Braam
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  4. W. Schmutzler
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Bent, S., Göttsch, C., Braam, U. et al. The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells. Agents and Actions 36 (Suppl 2), C321–C324 (1992). https://doi.org/10.1007/BF01997363

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  • DOI: https://doi.org/10.1007/BF01997363

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