Agents and Actions

, Volume 36, Supplement 2, pp C321–C324 | Cite as

The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells

  • S. Bent
  • C. Göttsch
  • U. Braam
  • W. Schmutzler
Plenary Lecture Histamine Release


The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4M. Cadmium increased the histamine release in adenoidal cells at 10−4M but in cutaneous cells only the stimulated release (10−8–10−5M) was affected. Bismuth inhibited the histamine release at 10−4M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.


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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • S. Bent
    • 1
  • C. Göttsch
    • 1
  • U. Braam
    • 1
  • W. Schmutzler
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieMedizinische Fakultät der RWTH AachenAachenFRG

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