Agents and Actions

, Volume 36, Supplement 2, pp C321–C324

The effects of heavy metal ions (Cd2+, Hg2+, Pb2+, Bi3+) on histamine release from human adenoidal and cutaneous mast cells

  • S. Bent
  • C. Göttsch
  • U. Braam
  • W. Schmutzler
Plenary Lecture Histamine Release

DOI: 10.1007/BF01997363

Cite this article as:
Bent, S., Göttsch, C., Braam, U. et al. Agents and Actions (1992) 36(Suppl 2): C321. doi:10.1007/BF01997363

Abstract

The influence of lead (Pb[CH3COO]2), mercury (HgCl2), cadmium (CdSO4) and bismuth (BiO[ClO4]) on the spontaneous and stimulated histamine release from human adenoidal and cutaneous mast cells was tested in the concentration range 10−8–10−4M. Lead displayed a bell shaped dose-response relationship in adenoidal mast cells with a maximum at 10−6M whereas in cutaneous cells only the spontaneous release was slightly enhanced at 10−4M. Mercury induced a presumably toxic histamine release in adenoidal and cutaneous mast cells at 10−4M. Cadmium increased the histamine release in adenoidal cells at 10−4M but in cutaneous cells only the stimulated release (10−8–10−5M) was affected. Bismuth inhibited the histamine release at 10−4M in the adenoidal mast cells only. In conclusion, human adenoidal and cutaneous mast cells are affected differently by metal ions.

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • S. Bent
    • 1
  • C. Göttsch
    • 1
  • U. Braam
    • 1
  • W. Schmutzler
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieMedizinische Fakultät der RWTH AachenAachenFRG

Personalised recommendations