Effects of vecuronium-induced histamineN-methyltransferase inhibition on cutaneous responses to histamine
Plenary Lecture Symposium on Histamine and Antihistamine in Anaesthesia and Surgery (ii) Mechanisms of Histamine Release in Anaesthesia and Surgery
All muscle relaxants inhibit histamineN-methyltransferasein vitro, but vecuronium, a steroid-derived muscle relaxant, is the most potent inhibitor. It has been suggested that administration of vecuronium prior to giving a drug that releases histamine may exaggerate the hemodynamic or vascular effects. Volunteers were injected intradermally with 5×10−4M concentrations of histamine, and the combination of vecuronium and histamine, to evaluate thein vivo significance. Vecuronium did not alter the measured wheal and flare responses to injected histamine at 5, 15, 30, 40, 50 and 60 mins. There is no evidence that inhibition of histamineN-methyltransferasein vivo will alter the vascular effects of histamine.
KeywordsHistamine Potent Inhibitor Muscle Relaxant Vascular Effect Vecuronium
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