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In vitro susceptibility of quinolone-resistantCampylobacter jejuni to new macrolide antibiotics

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Abstract

The MICs of erythromycin and three new macrolide antibiotics were determined for 36 quinolone-susceptible and 106 quinolone-resistantCampylobacter jejuni. The MIC90 values of azithromycin, clarithromycin, roxithromycin and erythromycin were 0.5, 4, 16 and 4 mg/l respectively. No difference was found between macrolide activity against the quinolone-susceptible and the quinolone-resistant strains. Clarithromycin and especially azithromycin might eventually replace erythromycin for the treatment ofCampylobacter jejuni infections in view of their pharmacological properties.

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Authors and Affiliations

  1. Department of Clinical Microbiology, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands

    H. P. Endtz & M. Broeren

  2. Department of Medical Microbiology, University Hospital Leiden, PO Box 9600, 2300 RC, Leiden, The Netherlands

    R. P. Mouton

Authors
  1. H. P. Endtz
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  2. M. Broeren
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  3. R. P. Mouton
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Endtz, H.P., Broeren, M. & Mouton, R.P. In vitro susceptibility of quinolone-resistantCampylobacter jejuni to new macrolide antibiotics. Eur. J. Clin. Microbiol. Infect. Dis. 12, 48–50 (1993). https://doi.org/10.1007/BF01997058

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