Abstract
Serum specimens from 223 patients with acute lower respiratory tract infection were examined for antibodies toChlamydia pneumoniae using the microimmunofluorescence test. Antibodies toChlamydia pneumoniae were detected in 18 (20 %) of 91 children and 64 (48 %) of 132 adults. Among those individuals, 4 (4 %) children and 15 (11 %) adults had elevated IgG antibody titres indicating acute or recent infection. Specific IgM antibodies were observed in two patients. These results suggest that a significant proportion of lower respiratory tract infections in Germany is caused byChlamydia pneumoniae.
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Grayston JT, Kuo CC, Campbell LA, Wang SP Chlamydia pneumoniae sp. nov. forChlamydia sp. strain TWAR. International Journal of Systematic Bacteriology 1989, 39: 88–90.
Grayston JT, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH, Wang SP A new respiratory tract pathogen:Chlamydia pneumoniae strain TWAR. Journal of Infectious Diseases 1990, 161: 618–625.
Saikku P, Mattila K, Nieminen MS, Huttunen JK, Leinonen M, Ekman MR, Mäkelä PH, Valtonen V Serological evidence of an association of a novelChlamydia, TWAR, with coronary heart disease and acute myocardial infarction. Lancet 1988, ii: 983–985.
Marrie TJ, Harczy M, Mann OE, Landymore RW, Raza A, Wang SP, Grayston JT Culture-negative endocarditis probably due toChlamydia pneumoniae. Journal of Infectious Diseases 1990, 161: 127–129.
Hahn DL, Dodge RW, Golubjatnikov R Association ofChlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. Journal of the American Medical Association 1991, 266: 225–230.
Haidl S, Ivarsson S, Bjerre I, Persson K Guillain-Barré syndrome afterChlamydia pneumoniae infection. New England Journal of Medicine 1992, 326: 576–577.
Wang SP, Grayston JT Population prevalence antibody toChlamydia pneumoniae, strain TWAR. In: Bowie WR, Caldwell HD, Jones RP, Mardh PA, Ridgway GL, Schachter J, Stamm WE, Ward ME (ed): Chlamydial infections. Proceedings of the Seventh International Symposium on Human Chlamydial Infections. Cambridge University Press, Cambridge, 1990, p. 402–405.
Marrie TJ, Grayston JT, Wang SP, Kuo CC Pneumonia associated with the TWAR strain ofChlamydia. Annals of Internal Medicine 1987, 106: 507–511.
Saikku P, Ruutu P, Leinonen M, Panelius J, Tupasi TE, Grayston JT Acute lower respiratory tract infection associated with chlamydial TWAR antibody in Filipino children. Journal of Infectious Diseases 1988, 158: 1095–1097.
Grayston JT, Diwan VK, Cooney M, Wang SP Community-and hospital-acquired pneumonia associated withChlamydia TWAR infection demonstrated serologically. Archives of Internal Medicine 1989, 149: 169–173.
Grayston TJ, Mordhorst C, Bruu AL, Vene S, Wang SP Countrywide epidemics ofChlamydia pneumoniae, strain TWAR, in Scandinavia, 1981–1983. Journal of Infectious Diseases 1989, 159: 1111–1114.
Chirgwin K, Roblin PM, Gelling M, Hammerschlag MR, Schachter J Infection withChlamydia pneumoniae in Brooklyn. Journal of Infectious Diseases 1991, 163: 757–761.
Grayston TJ, Kuo CC, Wang SP, Altmann J A newChlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. New England Journal of Medicine 1986, 315: 161–168.
Gordon FB, Harper IA, Quan AL, Treharne JD, Dwyer RSC, Garland JA Detection ofChlamydia (bedsonia) in certain infections of man. I: Laboratory procedures: comparison of yolk sac and cell culture for detection and isolation. Journal of Infectious Diseases 1969, 120: 451–462.
Kuo CC, Grayston JT Factors affecting viability and growth in HeLa 229 cells ofChlamydia sp. strain TWAR. Journal of Clinical Microbiology 1988, 26: 812–815.
Wang SP, Kuo CC, Grayston JT FormalinizedChlamydia trachomatis organisms as antigen in the micro-immunofluorescence test. Journal of Clinical Microbiology 1979, 10: 259–261.
Wang SP, Grayston JT Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. American Journal of Ophthalmology 1970, 70: 367–374.
Campbell JF, Barnes RC, Kozarsky PE, Spika JS Culture-confirmed pneumoniae. Journal of Infectious Diseases 1991, 164: 411–413.
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Jantos, C., Artelt, P. & Schiefer, H.G. Acute lower respiratory tract infection associated withChlamydia pneumoniae in Germany. Eur. J. Clin. Microbiol. Infect. Dis. 12, 33–35 (1993). https://doi.org/10.1007/BF01997053
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DOI: https://doi.org/10.1007/BF01997053