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A thermal analysis study of ascorbic acid and its pharmaceutical formulations

A consideration of time-temperature plots

  • Pharmaceuticals
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Abstract

In a previous publication, the thermogravimetric (TG) analysis of ascorbic acid was considered. Simultaneously with the production of the TG data, time-temperature plots were also generated on the work station which allowed the process to be classified as exothermic or endothermic and identified the energy change with the reaction sequence. This aspect is investigated in the present study. To maximize the energy change, the model mixtures were assessed at a mass ratio of 1∶1. The analytical implications of this approach are explored. To avoid complications in this kind of analysis, the present study is restricted to the behavior of binary systems heat treated in nitrogen.

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References

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Authors and Affiliations

  1. College of Pharmacy and Department of Chemistry, The University of Toledo, 43606, Toledo, OH, USA

    S. Lerdkanchanaporn, D. Dollimore & K. S. Alexander

Authors
  1. S. Lerdkanchanaporn
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  2. D. Dollimore
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  3. K. S. Alexander
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Lerdkanchanaporn, S., Dollimore, D. & Alexander, K.S. A thermal analysis study of ascorbic acid and its pharmaceutical formulations. Journal of Thermal Analysis 49, 887–896 (1997). https://doi.org/10.1007/BF01996774

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  • DOI: https://doi.org/10.1007/BF01996774

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