Solubility and glass transition in the system α-D-trehalose/water
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Precipitation of trehalose dihydrate in water is observed at room temperature for trehalose concentrations higher than 47.5%w/w. Direct observations of crystal melting in water and measures of the solution density determine the thermal variations of trehalose saturationS(T) (mM) in water: ln(S(T))=ln(0.1223)-(1330/T) withR 2 =0.9982. The glass transition (Tg) curve measured by DSC is lower at low concentrations and higher at high concentrations than previously reported.T g is also measured as a function of the cooling/warming rates. Analysis of specific heat changes atT g and associated activation energy leads to identify a most stable glassy state around the second eutectic concentration.
Keywordsglass transition phase diagram solubility trehalose water
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