Journal of thermal analysis

, Volume 49, Issue 2, pp 817–822 | Cite as

Solubility and glass transition in the system α-D-trehalose/water

  • P. M. Mehl
Biological/Life Sciences


Precipitation of trehalose dihydrate in water is observed at room temperature for trehalose concentrations higher than 47.5%w/w. Direct observations of crystal melting in water and measures of the solution density determine the thermal variations of trehalose saturationS(T) (mM) in water: ln(S(T))=ln(0.1223)-(1330/T) withR 2 =0.9982. The glass transition (Tg) curve measured by DSC is lower at low concentrations and higher at high concentrations than previously reported.T g is also measured as a function of the cooling/warming rates. Analysis of specific heat changes atT g and associated activation energy leads to identify a most stable glassy state around the second eutectic concentration.


glass transition phase diagram solubility trehalose water 


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Copyright information

© Akadémiai Kiadó 1997

Authors and Affiliations

  • P. M. Mehl
    • 1
  1. 1.Transfusion and Cryopreservation Research Program, NMRI, NNMCBethesdaUSA

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