Solubility and glass transition in the system α-D-trehalose/water
- 238 Downloads
Precipitation of trehalose dihydrate in water is observed at room temperature for trehalose concentrations higher than 47.5%w/w. Direct observations of crystal melting in water and measures of the solution density determine the thermal variations of trehalose saturationS(T) (mM) in water: ln(S(T))=ln(0.1223)-(1330/T) withR 2 =0.9982. The glass transition (Tg) curve measured by DSC is lower at low concentrations and higher at high concentrations than previously reported.T g is also measured as a function of the cooling/warming rates. Analysis of specific heat changes atT g and associated activation energy leads to identify a most stable glassy state around the second eutectic concentration.
Keywordsglass transition phase diagram solubility trehalose water
Unable to display preview. Download preview PDF.
- 2.L. M. Crowe and J. H. Crowe, Proc. Conference on Frozen Platelets and Platelet Substitutes in Transfusion Medicine, USUHS, Bethesda MD, 1996.Google Scholar
- 4.B. J. Aldous, A. D. Auffret and F. Franks, Proc.of the 1996 Colorado Protein Stability Conference, Breckenridge, Co, 7/10-13/1996.Google Scholar
- 6.C. T. Moynihan, in “Assignment of the glass transition” R. J. Seyler, Ed., 5TP1249, ASTM, Baltimore 1995, p. 32.Google Scholar
- 7.F. G. Shi, J. Materials Res., (1996) in press.Google Scholar
- 11.R. H. M. Hartley, B. Roser, J. Kampinga and J. Maki, Proc. of the 1996 Colorado Protein Stability Conference, Breckenridge, Co, 7/10-13, 1996.Google Scholar