Agents and Actions

, Volume 38, Issue 3–4, pp C263–C265 | Cite as

Effects of betahistine on locomotor activity and passive avoidance behavior in rats

  • X. A. Alvarez
  • A. Franco
  • L. Fernández-Novoa
  • R. Cacabelos
Histamine and the Nervous System


Brain histaminergic and cholinergic systems are involved in the neuromodulation of cognitive functions and altered in some neuropsychiatric disorders such as Alzheimer's disease. In this study we have investigated the effects of betahistine dihydrochloride (BH) on locomotor activity (LA) and passive avoidance behavior (PAB) in control and scopolamine(SC)-treated male rats. In an open-field paradigm, BH increased LA at high doses and inhibited SC-induced hyperactivity at moderate ones, without effect on motor habituation. In an electronic maze paradigm, in which animals had to learn to avoid a 1.5 mA electric shock, BH reduced the number of trials required by SC-treated animals to learn to stay in a neutral platform during two consecutive trials. These results seem to indicate that BH influences basal and SC-induced locomotor activity, and attenuates the learning impairment caused by SC.


Cognitive Function Locomotor Activity Scopolamine Passive Avoidance Electric Shock 
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  1. [1]
    R. Cacabelos,Histaminergic system: Neuroendocrine function of brain histamine. Meth. Find. Exp. Clin. Pharmacol.12, 341–376 (1990).Google Scholar
  2. [2]
    J. S. Meyer, N. T. Mathew, A. Hartmann et al.,Orally administered betahistine and regional cerebral blood flow in cerebrovascular disease. J. Clin. Pharmacol.14, 280–289 (1974).PubMedGoogle Scholar
  3. [3]
    J. Pathy, G. Menon, A. Reynolds and R. Van Strik,Betahistine hydrochloride (Serc) in cerebrovascular disease: a placebo-controlled study. Age Ageing6, 179–184 (1977).PubMedGoogle Scholar
  4. [4]
    M. C. Gerald and R. P. Maickel,Studies on the possible role of brain histamine in behavior. Br. J. Pharmacol.44, 462–671 (1972).PubMedGoogle Scholar
  5. [5]
    J. M. Arrang, M. Garbarg, T. T. Quach, M. D. T. Tuong, E. Yeramia and J. C. Schwartz,Actions of betahistine at histamine receptors in the brain. Eur. J. Pharmacol.111, 73–84 (1985).PubMedGoogle Scholar
  6. [6]
    H. Niigawa, K. Nakamura, S. Hariguchi, T. Nishimura and R. Cacabelos,Effects of chronic administration of L-histidine on behavior and learning. A computerized analysis with OUCEM-86 system. Anu. Psiquiat.1, 287–298 (1990).Google Scholar
  7. [7]
    R. Cacabelos and X. A. Alvarez,Histidine decarboxylase inhibition induced by alpha-fluoromethylhistidine provokes learning-related hypokinetic activity. Agents and Actions33, 131–134 (1991).PubMedGoogle Scholar
  8. [8]
    K. Tasaka and C. Kamei,Effect of histamine on memory impairment ensuing from a long interruption of training or from hippocampal lesion in rats. Abstracts book of the XXI annual meeting of the European Histamine Research Society (Torremolinos-Málaga, Spain), p. 114 (1992).Google Scholar

Copyright information

© Birkhäuser Verlag 1993

Authors and Affiliations

  • X. A. Alvarez
    • 1
  • A. Franco
    • 1
  • L. Fernández-Novoa
    • 1
  • R. Cacabelos
    • 1
  1. 1.Department of Biomedical Research and Psychogeriatrics, Institute for CNS DisordersBasic and Clinical Neurosciences Research CenterCoruñaSpain

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