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, Volume 38, Issue 3–4, pp C248–C250 | Cite as

Histaminergic (H1) modulation of antinociception in morphinetolerant mice

  • S. M. Owen
  • G. Sturman
  • P. Freeman
Histamine and the Nervous System

Abstract

This study compares the actions of diphenhydramine (a centrally penetrating histamine H1-antagonist) and acrivastine (a peripherally acting H1-antagonist) in morphine-tolerant and morphine-naïve mice. Mice receivei morphine twice daily for 5–7 days to induce tolerance. Once tolerant, the mice again received morphine, this time after pre-treatment with diphenhydramine (30 mg/kg s.c.) or acrivastine (10 mg/kg s.c. or 5 μg intracerebroventricularly-i.c.v.). Diphenhydramine (s.c.) and acrivastine (i.c.v.) increased the action of morphine in the hot-plate test at 49±1°C. However, acrivastine (s.c.) had no effect. In morphine-naïve mice, diphenhydramine increased the antinociceptive action of morphine (5 mg/kg) as did acrivastine when given intracerebroventricularly but not subcutaneously. Therefore, H1-antagonists potentiate the antinociceptive action of morphine in both morphine-tolerant and morphine-naïve mice via a central, rather than peripheral, action.

Keywords

Morphine Histamine Diphenhydramine Antinociceptive Action Acrivastine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Birkhäuser Verlag 1993

Authors and Affiliations

  • S. M. Owen
    • 1
  • G. Sturman
    • 1
  • P. Freeman
    • 1
  1. 1.Department of Life SciencesUniversity of East LondonLondon

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