Loratadine is endowed with antiallergic activity. It reduces both the immunological release of histamine in active anaphylaxis of isolated guinea-pig mast cells and in anti-IgE challenged human basophils as well as the non-immunological release of histamine induced by compound 48/80 and calcium ionophore A 23187 in isolated purified rat serosal mast cells. Loratadine was also found capable of directly reducing platelet aggregation induced by different agonists in a concentration-dependent fashion. It is capable of blocking the potentiation afforded by histamine on human platelet aggregation induced by thrombin, collagen and arachidonic acid. The present results suggest a broader profile for loratadine beyond its original role as a non-sedative anti-H1-antihistaminic drug.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
W. Kreutner, A. Chapman, A. Gulbenkian and M. I. Siegel,Antiallergic activity of loratadine, a non-sedating antihistamine. Allergy42, 57–63 (1987).
D. M. Temple and M. McCluskey,Loratadine, an antihistamine, blocks antigen and ionophore-induced leukotriene release from human lung in vitro. Prostaglandins35, 549–554 (1988).
D. L. Emery, M. I. Siegel, F. M. Cuss, M. R. Danzig, J. E. Fish and S. P. Peters,Loratadine inhibits mediator release from dispersed human lung mast cells. Clin. Exp. Allergy20, 40–46 (1990).
P. F. Mannaioni, A. Pistelli, F. Gambassi, M. G. di Bello, S. Raspanti and E. Masini,A place for free radicals in plateletderived histamine releasing factor (PDHRF) and evidence that histaminergic receptors modulate platelet aggregation. Agents Actions33, 57–60 (1991).
E. Masini, B. Palmerani, F. Gambassi, A. Pistelli, E. Giannella, B. Occupati, M. Ciuffi, T. Bani Sacchi and P. F. Mannaioni,Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. Biochem. Pharmacol.39, 879–889 (1991).
F. L. Pearce and M. Ennis,Isolation and some properties of mast cells from the mesentery of the rat and guinea pig. Agents Actions10, 124–131 (1980).
M. W. Radomski and S. Moncada,An improved method for washing of human platelet with prostacyclin. Thromb. Res.30, 383–389 (1983).
J. H. Ovelgönne, A. W. J. M. Bol, W. C. J. Hop and R. van Wijk,Mechanical agitation of very dilute antiserum against IgE has no effect on basophil staining properties. Experientia48, 504–508 (1992).
About this article
Cite this article
Pistelli, A., Di Bello, M.G., Raspanti, S. et al. New pharmacological profiles of loratadine: Effects on platelet aggregation and histamine release from repository cells. Agents and Actions 38, C200–C202 (1993). https://doi.org/10.1007/BF01996459
- Mast Cell
- Platelet Aggregation