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New pharmacological profiles of loratadine: Effects on platelet aggregation and histamine release from repository cells

Abstract

Loratadine is endowed with antiallergic activity. It reduces both the immunological release of histamine in active anaphylaxis of isolated guinea-pig mast cells and in anti-IgE challenged human basophils as well as the non-immunological release of histamine induced by compound 48/80 and calcium ionophore A 23187 in isolated purified rat serosal mast cells. Loratadine was also found capable of directly reducing platelet aggregation induced by different agonists in a concentration-dependent fashion. It is capable of blocking the potentiation afforded by histamine on human platelet aggregation induced by thrombin, collagen and arachidonic acid. The present results suggest a broader profile for loratadine beyond its original role as a non-sedative anti-H1-antihistaminic drug.

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Pistelli, A., Di Bello, M.G., Raspanti, S. et al. New pharmacological profiles of loratadine: Effects on platelet aggregation and histamine release from repository cells. Agents and Actions 38, C200–C202 (1993). https://doi.org/10.1007/BF01996459

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Keywords

  • Mast Cell
  • Histamine
  • Thrombin
  • Platelet Aggregation
  • Loratadine