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H1 and H2 histamine receptors in human mammary carcinomas

  • Histamine in Cell Growth and Cancer
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Abstract

We previously reported the presence of H1 and H2 histamine receptors in an experimental mammary carcinoma induced in rats. Experiments carried outin vivo andin vitro indicate that by acting on these receptors, histamine and antagonists modulate tumor growth. In the present study, binding experiments were performed with human breast cancer biopsies. All the tumors examined exhibited specific binding sites for histamine. Some of them showed the high and low affinity double site previously characterized in the experimental carcinoma. The high affinity site Kd=18±6 nM, 50±33 fm/mg, exhibits H2 binding characteristics while the low affinity one, Kd=54±22 nM and 217±173 fm/mg, corresponds to an H1 receptor, Approximately 30% of the tumors studied were negative for H2 receptors while all of them showed specific binding for [3H]-mepyramine. These data suggest that histamine may regulate cell growth in a high proportion of human mammary carcinomas, offering possibilities for new therapeutic alternatives.

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Authors and Affiliations

  1. Cátedra de Física, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113, Buenos Aires, Argentina

    C. A. Davio, G. P. Cricco, R. M. Bergoc & E. S. Rivera

  2. Instituto de Oncología Angel H. Roffo, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    N. Andrade

Authors
  1. C. A. Davio
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  2. G. P. Cricco
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  3. N. Andrade
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  4. R. M. Bergoc
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  5. E. S. Rivera
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Davio, C.A., Cricco, G.P., Andrade, N. et al. H1 and H2 histamine receptors in human mammary carcinomas. Agents and Actions 38, C172–C174 (1993). https://doi.org/10.1007/BF01996450

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  • DOI: https://doi.org/10.1007/BF01996450

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