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Histamine metabolism in patients with foregut carcinoid tumours

  • Histamine in Cell Growth and Cancer
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Abstract

The urinary excretion of the histamine metabolite, tele-methylimidazoleacetic acid (MemAA), was measured in 15 patients with foregut carcinoid tumours (5 ECLomas, 4 gastric carcinoids of the mixed type and 6 bronchial carcinoids), High levels were related to tumour burden and presence of the foregut carcinoid syndrome. Control of symptoms was either achieved by octreotide in combination with blockade of histamine receptors or by hyperthermic liver perfusion chemotherapy. MemAA served as an exellent tumour marker for diagnosis and guidance of therapy.

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Authors and Affiliations

  1. Department of Clinical Physiology, University Hospital of Linköping, S-581 85, Linköping, Sweden

    G. Granerus & H. Ahlman

  2. Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden

    G. Granerus & H. Ahlman

Authors
  1. G. Granerus
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  2. H. Ahlman
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Additional information

This work was supported by grants from the Swedish MRC (5520), Jubileumsklinikens Cancer Research Fund and Landstinget, Östergötland.

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Granerus, G., Ahlman, H. Histamine metabolism in patients with foregut carcinoid tumours. Agents and Actions 38, C165–C168 (1993). https://doi.org/10.1007/BF01996448

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  • DOI: https://doi.org/10.1007/BF01996448

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