Agents and Actions

, Volume 36, Issue 3–4, pp C112–C114 | Cite as

Desferrioxamine potentiated SOD antiinflammatory activity in rat adjuvant arthritis: Role of iron and bacterial toxins

  • G. Benoni
  • L. Cuzzolin
  • D. Zambreri
  • I. Caramazza
  • P. Del Soldato
  • P. Caliceti
  • A. Conforti
Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy Short Communication General Inflammation
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Abstract

In this paper we studied the modulating inflammatory activity of iron in the adjuvant arthritis, taking indomethacin as a standard antiinflammatory drug and a superoxide dismutase derivative (MPEG-SOD) as a scavenger of free radicals. Moreover, we evaluated the changes in potential intestinal pathogens requiring iron for growth, in order to study the role of bacteria in the altered gastrointestinal functions observed during arthritis. We observed a 50% arthritis inhibition on the 14th day with MPEG-SOD plus desferrioxamine, a significant decrease in serum iron in arthritic rats compared to controls, and a significantCl. perfringens increase on the 28th day in the presence of MPEG-SOD. Our data demonstrate that hypoferremia, in arthritis, is a protective mechanism overall in the early phase and could protect the intestinal tract by inhibiting the development of potential pathogens.

Keywords

Iron Arthritis Superoxide Superoxide Dismutase Indomethacin 

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • G. Benoni
  • L. Cuzzolin
  • D. Zambreri
  • I. Caramazza
    • 1
  • P. Del Soldato
    • 1
  • P. Caliceti
    • 2
  • A. Conforti
  1. 1.Institute of PharmacologyUniversity of Verona, Italfarmaco ResearchMilano
  2. 2.Department of Pharmaceutical ScienceUniversity of PadovaItaly

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