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, Volume 36, Issue 3–4, pp C106–C108 | Cite as

Effect of non-steroidal anti-inflammatory drugs on glutathione levels in various organs of rat

  • L. Micheli
  • A. I. Fiaschi
  • G. Giorgi
  • D. Cerretani
Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy Short Communication General Inflammation

Abstract

Since glutathione (GSH) depletion (about 20% of total GSH content) can impair the cell's defence against the toxic actions of drugs and may lead to cell injury and death, we examined the effect of piroxicam, naproxen and ketoprofen on GSH levels in various organs of the rat (brain, eye, liver, stomach, heart, leg adductor muscle). Ketoprofen in brain and leg adductor muscle dramatically decreases the GSH levels, giving rise to potential cellular toxicity.

Keywords

Glutathione Adductor Muscle Naproxen Cell Injury Piroxicam 

References

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • L. Micheli
    • 1
  • A. I. Fiaschi
    • 1
  • G. Giorgi
    • 1
  • D. Cerretani
    • 1
  1. 1.Istituto di FarmacologiaUniversità degli StudiSienaItaly

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