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, Volume 36, Issue 3–4, pp C15–C17 | Cite as

Chronic intrajejunal TNBS application in TNBS-sensitized rats: A new model of chronic inflammatory bowel diseases

  • N. Selve
Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy Experimental Aspects of Gastrointestinal Inflammation


An enteritis, based on a delayed-type hypersensitivity reaction, was induced in TNBS (2,4,4-trinitrobenzenesulfonic acid) sensitized rats by intrajejunal challenge with TNBS. This treatment induced a chronic inflammation of the distal small intestine, characterized by gross hyperaemia and oedema, as assessed by a macroscopic score. Histologically, the inflammatory response included cell infiltration by lymphocytes and histiocytes, a transmural granulomatous inflammation with multinucleated cells and activated mesenteric lymph nodes. Drug treatment with sulfasalazine or 5-aminosalicylic acid improved enteritis score. The applicability and relevance of this new model is discussed in relation to drug development and basic research of inflammatory bowel diseases.


Lymph Node Inflammatory Response Inflammatory Bowel Disease Small Intestine Drug Treatment 
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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • N. Selve
    • 1
  1. 1.Department of Pharmacology, Center of ResearchGrünenthal GmbHAachenFRG

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