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, Volume 36, Issue 3–4, pp C3–C9 | Cite as

Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat

  • Nigel K. Boughton-Smith
  • Angela M. Deakin
  • Brendan J. R. Whittle
Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy Experimental Aspects of Gastrointestinal Inflammation


The actions of nitric oxide (NO) on the acute gastrointestinal damage induced by platelet-activating factor (PAF) have been investigated in the rat.S-nitroso-N-acetyl penicillamine, which spontaneously generates NO, dose-dependently inhibited PAF-induced gastrointestinal plasma leakage, a measure of the initiation of vascular damage. The inhibitor of NO synthase,NG-monomethyl-l-arginine substantially potentiated gastrointestinal damage and plasma leakage induced byE. coli endotoxin, but had no effect on that induced by intravenous infusion of PAF.

Endogenous NO may thus have a protective role in the gastrointestinal vascular that can be mimicked by generators of NO. The protection afforded by endogenous NO may, however, be dependent on the nature of the inflammatory stimulus used to induce gastrointestinal damage.


Oxide Nitric Oxide Protective Role Intravenous Infusion Penicillamine 
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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • Nigel K. Boughton-Smith
    • 1
  • Angela M. Deakin
    • 1
  • Brendan J. R. Whittle
    • 1
  1. 1.Department of PharmacologyWellcome Research LaboratoriesBeckenhamUK

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