Skip to main content
Log in

The offspring of mothers with anorexia nervosa: A high-risk group for undernutrition and stunting?

  • Nutrition
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Seven children from three families presented with stunting and low weight-for-height. Their mothers had a history of anorexia nervosa (AN). Evidence was gathered that the children were nourished insufficiently, possibly in combination with psychosocial deprivation. Low growth hormone secretion was documented in three cases. With the increasing ability to induce fertility in anorectic women one should be aware of the effects of maternal AN on the offspring.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

AN:

anorexia nervosa

GH:

growth hormone

PSD:

psychosocial deprivation

References

  1. Davies DP (1979) Is inadequate breastfeeding an important cause of failure to thrive? Lancet I:541–542

    Google Scholar 

  2. Frasier DS, Rallison ML (1972) Growth retardation and emotional deprivation: relative resistance to treatment with human growth hormone. J Pediatr 80:603–609

    PubMed  Google Scholar 

  3. Frisch RE, Mc Arthur JW (1974) Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 185:949–951

    PubMed  Google Scholar 

  4. Frisch RE, Revelle R (1970) Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169:397–399

    PubMed  Google Scholar 

  5. Furlanetto RW, Underwood LE, Wijk JJ van, D'Ercole AJ (1977) Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 60:648–657

    PubMed  Google Scholar 

  6. Gull W (1988) Anorexia nervosa. Lancet I:62–65

    Google Scholar 

  7. Holmes NE, Blethen SL, Weldon VV (1984) Somatomedin-C response to growth hormone in psychosocial growth retardation. Am J Med Sc 288:86–88

    Google Scholar 

  8. Kohmura H, Miyake A, Aono T, Tanizawa O (1986) Recovery of reproductive function in patients with anorexia nervosa: a 10-year follow-up study. Eur J Obstet Gynecol Reprod Biol 22:293–296

    PubMed  Google Scholar 

  9. Krieger I (1974) Food restriction as a form of child abuse in ten cases of psychosocial deprivation dwarfism. Clin Pediatr 13:127–133

    Google Scholar 

  10. Krieger I, Mellinger RC (1979) Pituitary function in the deprivation syndrome. J Pediatr 171:216–225

    Google Scholar 

  11. Money J (1977) The syndrome of abuse dwarfism (Psychosocial dwarfism or reversible hyposomatotropism) Am J Dis Child 131: 508–513

    PubMed  Google Scholar 

  12. Powell GF, Brasel JA, Blizzard RM (1967) Emotional deprivation and growth retardation simulating idiopathic hypopituitarism. I Clinical evaluation of the syndrome. N Engl J Med 276:1271–1278

    PubMed  Google Scholar 

  13. Powell, GF, Brasel JA, Raiti S, Blizzard RM (1967) Emotional deprivation and growth retardation simulating idopathic hypopituitarism. II. Endocrinologic evaluation of the syndrome. N Engl J Med 276:1279–1283

    PubMed  Google Scholar 

  14. Powell GF, Hopwood NJ, Banat ES (1973) Growth hormone studies before and during catch-up growth in a child with emotional deprivation and short stature. J Clin Endocrinol Metab 37: 674–679

    PubMed  Google Scholar 

  15. Roede MJ, Wieringen JC van (1985) Growth diagrams 1980, the Netherlands. Third nation-wide survey. T Soc Gezondheidszorg 63 [Suppl]:1–34

    Google Scholar 

  16. Russel Davis D, Apley J, Fill G, Grimaldi C (1978) Diet and retarded growth. Br Med J 1:539–542

    PubMed  Google Scholar 

  17. Silver HK, Finkelstein M (1967) Deprivation dwarfism. J Pediatr 70:317–324

    PubMed  Google Scholar 

  18. Skuse DH (1985) Non-organic failure to thrive: a reappraisal. Arch Dis Child 60:173–178

    PubMed  Google Scholar 

  19. Stanhope P, Hamill G, Adlard P, Jones J, Skuse D, Preece MA (1988) Physiological growth hormone secretion during the recovery from psychosocial dwarfism: a case report Clin Endocrinol (Oxf) 28:335–339

    Google Scholar 

  20. Van den Brande JL (1975) Plasma somatomedin. Clinical observations. In: Pecile A, Muller EE (eds) Growth hormone and related peptides. Excerpta Medica, Amsterdam, pp 271–285

    Google Scholar 

  21. Van den Brande JL, DuCaju MVL (1974) An improved technique for measuring somatomedin activity in vitro. Acta Endocrinol 75: 233–242

    PubMed  Google Scholar 

  22. Van den Brande JL, Buul S van, Heinrich U, Roon F van, Zurcher T, Steirtegem AC van (1975) Further observations on plasma somatomedin activity in children. In: Advances in metabolic disorders, vol 8: somatomedins and some other growth factors. Academic Press, New York, pp 171–181

    Google Scholar 

  23. Waldhauser F, Toifl K, Spona J, Frisch H (1986) Basale Gonado-tropinspiegel und Gonadotropinstimulierbarkeit bei Patientinnen mit Anorexia nervosa. Wien Klin Wochenschr 98:393–397

    PubMed  Google Scholar 

  24. Whitten CF, Petit MG, Fischoff J (1969) Evidence that growth failure from maternal deprivation is secondary to undereating. JAMA 209:1675–1682

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Wezel-Meijler, G., Wit, J.M. The offspring of mothers with anorexia nervosa: A high-risk group for undernutrition and stunting?. Eur J Pediatr 149, 130–135 (1989). https://doi.org/10.1007/BF01995864

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01995864

Key words

Navigation