Abstract
A newborn infant was diagnosed as having renal vein thrombosis due to heterozygous protein C deficiency and no other predisposing factor for thrombosis. He responded adequately to treatment with streptokinase, fresh frozen plasma and subsequent anticoagulation with heparin and warfarin (Coumadin). Four years from diagnosis he remains well with no recurrence of thrombosis and with normal renal function.
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Abbreviations
- IVC:
-
Inferior vena cava
References
Branson HE, Katz J, Marble R, Griffin JH (1983) Inherited protein C deficiency and coumadin-responsive chronic relapsing purpura fulminans syndrome in a newborn infant. Lancet II:1165–1168
Broekmans AW, Veltkamp JJ, Bertina RM (1983) Congenital protein C deficiency and venous thromboembolism. N Engl J Med 309:340–344
Clouse LH, Comp PC (1986) The regulation of hemostasis: the protein C system. N Engl J Med 314:1298–1304
Comp PC, Nixon RR, Esmon CT (1984) Determination of functional levels of protein C, an antithrombotic protein using thrombin-thrombomodulin complex. Blood 63:15–21
Karpatkin M, Mannucci PM, Bhogal M, Vigano S, Nardi M (1986) Low protein C in the neonatal period. Br J Haematol 62:137–142
Mannucci PM, Vigano S (1982) Deficiencies of protein C, an inhibitor of blood coagulation. Lancet II:463–467
Miletech J, Sherman L, Broze G (1987) Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med 317:991–996
Nardi M, Karpatkin M (1986) Prothrombin and protein C in early childhood: normal adult levels are not achieved until the fourth year of life. J Pediatr 109:843–845
Pritchard SL, Culham JAG, Rogers PCJ (1985) Low dose fibrinolytic therapy in infants. J Pediatr 106:594–598
Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivehn A, Rapaport SI (1984) Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med 310: 559–562
Yeun P, Cheung A, Lin HJ, Ho F, Mimuro J, Yoshida N, Aoki N (1986) Purpura fulminans in a Chinese boy with congenital Protein C deficiency. Pediatrics 77:670–676
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Rogers, P.C.J., Silva, M.P., Carter, J.E.J. et al. Renal vein thrombosis and response to therapy in a newborn due to protein C deficiency. Eur J Pediatr 149, 124–125 (1989). https://doi.org/10.1007/BF01995862
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DOI: https://doi.org/10.1007/BF01995862