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SH reactivity of cigarette smoke and its correlation with carcinogenic effects on hamster lung cultures

SH-Reaktivität von Zigarettenrauch und ihre Korrelation mit karzinogenen Wirkungen auf die Hamster-Lungenkultur

Réactivité au SH de la fumée de cigarettes et sa correlation avec les effets carcinogènes sur les cultures du poumon d'hamsters

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Sozial- und Präventivmedizin

Summary

After hamster lung cultures were exposed repeatedly to puffs of fresh smoke from 7 types of cigarettes containing variable amounts of particulate and gas vapour phase components, atypical growth and/or malignant cell transformation were observed within a period of 3–6 months. A positive correlation was demonstrable between high SH reactivity and high NO content of the gas vapour phase and malignant transformation. There was no positive correlation for the other analyzed components of the smoke, including tar content.

Zusammenfassung

Die wiederholte Berauchung von Hamster-Lungenzellkulturen mit frischem Rauch von 7 Zigarettenarten mit unterschiedlichen Mengen Teilchenphase- und Gas-Dampf-Phase-Komponenten führte innerhalb eines 3–6monatigen Zeitraumes zu atypischem Wachstum und/oder bösartigen Zellveränderungen. Zwischen hoher SH-Reaktivität sowie hohem NO-Gehalt der Gas-Dampf-Phase und bösartigen Veränderungen wurde eine positive Korrelation nachgewiesen, während die anderen untersuchten Rauchkomponenten, darunter der Teergehalt, keine positive Korrelation zeigten.

Résumé

L'exposition de cultures cellulaires de poumons d'hamsters à la fumée fraîche de 7 types de cigarettes avec quantités variables des facteurs chimiques de la phase particulaire et de la phase vapeur-gaz a resulté après une période de 3–6 mois dans une croissance atypique et/ou dans une transformation cellulaire maligne. Une corrélation positive a été démontrée entre une haute réactivité SH ainsi qu'une haute teneur en NO de la phase gaz-vapeur et la transformation maligne. Il n'y avait aucune correlation positive avec les autres facteurs chimiques analysés, dont la tenue en goudron.

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References

  1. C. Apffel, J. Walker andS. Issarescu Tumor Rejection in Experimental Animals Treated with Radioprotective Thiols. Cancer Research35 429 (1975).

    PubMed  Google Scholar 

  2. M. L. Fenner andJ. Braven The mechanism of carcinogenesis by tobacco smoke. Further experimental evidence and a prediction from the thiol-defence hypothesis. Brit. Journ. Cancer22 474 (1968).

    Google Scholar 

  3. D. Hoffmann and J. Vals: Analysis of volatile N-nitrosamines in unaged mainstream smoke of cigarettes. Paper presented at the 25th Tobacco Chemists' Research Conference, Louisville, Ky, USA, October 6–8, 1971.

  4. P. D. Jocelyn Biochemistry of the SH group. Academic Press, London, New York 1972, pp. 1–404.

    Google Scholar 

  5. G. Kallistros Verhinderung der 3,4-benzopyrene-Karzinogenese durch natürliche und synthetische Verbindungen. Münch. med. Wschr.117 391 (1975).

    Google Scholar 

  6. R. Lange Inhibiting Effect of Tobacco Smoke on Some Crystalline Enzymes. Science, N.Y.134 52 (1961).

    Google Scholar 

  7. C. Leuchtenberger andR. Leuchtenberger Differential cytological and cytochemical responses of various cultures from mouse tissues to repeated exposures to puffs from the gas phase of charcoal-filtered fresh cigarette smoke. Exptl. Cell Res.62 161 (1970).

    Article  PubMed  Google Scholar 

  8. C. Leuchtenberger andR. Leuchtenberger: Effects of chronic inhalation of whole fresh cigarette smoke and of its gas phase on pulmonary tumorigenesis in Snell's mice. In: US Atomic Energy Commission, Division of Technical Information, 21st AEC Symposium Series: Morphology of experimental respiratory carcinogenesis, 329–346 (1970).

  9. C. Leuchtenberger, R. Leuchtenberger andA. Schneider Effects of marijuana and tobacco smoke on human lung physiology. Nature241 137 (1973).

    Article  PubMed  Google Scholar 

  10. C. Leuchtenberger, R. Leuchtenberger, N. Inui andU. Ritter Effects of Marijuana and Tobacco Smoke on DNA and Chromosomal Complement in Human Lung Explants. Nature242 403 (1973).

    Article  PubMed  Google Scholar 

  11. C. Leuchtenberger andR. Leuchtenberger The experimental exploration of health damaging factors in cigarette smoke. Sozial- und Präventivmedizin19 41 (1974).

    Article  Google Scholar 

  12. C. Leuchtenberger andR. Leuchtenberger: Differential Response of Snell's and C57 Black Mice to Chronic Inhalation of Cigarette Smoke. Pulmonary Carcinogenesis and Vascular Alterations in Lung and Heart. Oncology29 122 (1974).

    PubMed  Google Scholar 

  13. C. Leuchtenberger, R. Leuchtenberger andI. Zbinden Gas Vapour Phase Constituents and SH Reactivity of Cigarette Smoke Influence Lung Cultures. Nature247 No 5442, 565 (1974).

    Article  PubMed  Google Scholar 

  14. C. Leuchtenberger andR. Leuchtenberger: Correlated cytological and cytochemical studies of the effects of fresh smoke from marijuana cigarettes on growth and DNA metabolism of animal and human cultures. Proceedings of the International Conference on the Pharmacology of Cannabis, Savannah, Georgia, in press (1975).

  15. G. M. Powell andG. M. Green Cigarette smoke — A proposed metabolic lesion in alveolar macrophages. Bioch. Pharmac.21 1785 (1972).

    Article  Google Scholar 

  16. T. Sato, T. Suruki andT. Fukijama Cigarette Smoke: Mode of adhesion and haemolyzing and SH-inhibiting factors. Br. J. Cancer16 7 (1962).

    Google Scholar 

  17. US Department of Health, Education and Welfare, Public Health Service, Health Services and Mental Health Administration: The Health Consequences of Smoking, a report to the Surgeon General (1973) 1–249.

  18. E. L. Wynder andD. Hoffmann Tobacco Smoke, studies in experimental carcinogenesis. Academic Press, New York-London 1967, 1–730.

    Google Scholar 

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Authors and Affiliations

  1. Department of Cytochemistry, Swiss Institute for Experimental Cancer Research, Lausanne

    Cecilie Leuchtenberger, Rudolf Leuchtenberger, Irene Zbinden & Elisabeth Schleh

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  1. Cecilie Leuchtenberger
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  2. Rudolf Leuchtenberger
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  3. Irene Zbinden
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  4. Elisabeth Schleh
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Leuchtenberger, C., Leuchtenberger, R., Zbinden, I. et al. SH reactivity of cigarette smoke and its correlation with carcinogenic effects on hamster lung cultures. Soz Präventivmed 21, 47–50 (1976). https://doi.org/10.1007/BF01994377

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