Lactobacillus casei-induced polyarthritis in Lewis rats: Histopathological scoring system for evaluation of anti-rheumatic drugs
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A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption inL. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2–60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation.
KeywordsArthritis Animal Model Lactobacillus Bone Resorption Therapeutic Agent
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