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, Volume 34, Issue 1–2, pp 232–234 | Cite as

Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees

  • E. M. O'Byrne
  • R. L. Goldberg
  • J. R. Doughty
  • M. Wong
  • V. Blancuzzi
  • D. Wilson
  • A. Y. Jeng
Osteoarthritis

Abstract

The effect of SP on recombinant human IL-1α-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 μg SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 μg Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees.

Keywords

Cartilage Degradation Rabbit Knee Induce Cartilage Degradation Increase Cartilage Degradation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • E. M. O'Byrne
    • 1
  • R. L. Goldberg
    • 1
  • J. R. Doughty
    • 1
  • M. Wong
    • 1
  • V. Blancuzzi
    • 1
  • D. Wilson
    • 1
  • A. Y. Jeng
    • 1
  1. 1.Pharmaceuticals Division, Research DepartmentCIBA-GEIGY CorporationSummitUSA

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