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, Volume 34, Issue 1–2, pp 151–155 | Cite as

15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice

  • H. U. Schorlemmer
  • R. R. Bartlett
  • F. R. Seiler


Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited.


Rheumatoid Arthritis Arthritis Urea Creatinine Renal Function 


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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • H. U. Schorlemmer
    • 1
  • R. R. Bartlett
    • 2
  • F. R. Seiler
    • 1
  1. 1.Research Laboratories of Behringwerke AGMarburg/LahnFRG
  2. 2.Pharmacology Kalle-AlbertHoechst AGWiesbadenFRG

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