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, Volume 34, Issue 1–2, pp 151–155 | Cite as

15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice

  • H. U. Schorlemmer
  • R. R. Bartlett
  • F. R. Seiler
Autoimmunity

Abstract

Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited.

Keywords

Rheumatoid Arthritis Arthritis Urea Creatinine Renal Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • H. U. Schorlemmer
    • 1
  • R. R. Bartlett
    • 2
  • F. R. Seiler
    • 1
  1. 1.Research Laboratories of Behringwerke AGMarburg/LahnFRG
  2. 2.Pharmacology Kalle-AlbertHoechst AGWiesbadenFRG

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