Agents and Actions

, Volume 34, Issue 1–2, pp 151–155 | Cite as

15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice

  • H. U. Schorlemmer
  • R. R. Bartlett
  • F. R. Seiler
Autoimmunity

Abstract

Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited.

Keywords

Rheumatoid Arthritis Arthritis Urea Creatinine Renal Function 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    H. Iwasawa, S. Kando, D. Ikeda, T. Takeuchi and H. Umezawa,Synthesis of (−)-15-Deoxyspergualin and (−)Spergualin-15-phosphate. J. Antibiot.35, 1665–1669 (1982).PubMedGoogle Scholar
  2. [2]
    H. U. Schorlemmer, R. R. Barlett, R. Schleyerbach, G. Dickneite and F. R. Seiler,Immunosuppressive therapy of experimental autoimmune disease like rheumatoid arthritis and systemic lupus erythematosus by 15-Deoxyspergualin. Int. J. Immunotherapy5, 9–20 (1989).Google Scholar
  3. [3]
    H. U. Schorlemmer, G. Dickneite, H. H. Sedlacek, and F. R. Seiler,Therapeutic treatment with 15-Deoxyspergualin (15-DOS) of acute and chronic relapsing experimental allergic encephalomyelitis (EAE), models for multiple sclerosis (MS). In:Recent Advances in Chemotherapy (Eds. E. Rubinstein and D. Adam) pp. 8611–8612, E. Lewin-Epstein Ltd. Offset Printers, Jerusalem, Israel (1989).Google Scholar
  4. [4]
    E. D. Murphy and J. B. Roths,Autoimmunity and lymphoproliferation: induction by mutant gene 1pr and acceleration by a male-associated factor in strain BxSB mice. InGenetic control of autoimmune disease. (Eds. N. Rose, P. Bigazzi and N. Warner) Elsevier, North-Holland, New York, pp. 207–211 (1978).Google Scholar
  5. [5]
    K. Phadke, R. Fouts, J. Parrish, and R. S. Baker,Autoreactivity to collagen in murin lupus model. Arthritis Rheum.27, 313–319 (1984).PubMedGoogle Scholar
  6. [6]
    A. Pataki and C. Rordorf-Adam,Polyarthritis in MRL-1pr/1pr mice. Rheumatol. Inst.5, 113–120 (1985)CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • H. U. Schorlemmer
    • 1
  • R. R. Bartlett
    • 2
  • F. R. Seiler
    • 1
  1. 1.Research Laboratories of Behringwerke AGMarburg/LahnFRG
  2. 2.Pharmacology Kalle-AlbertHoechst AGWiesbadenFRG

Personalised recommendations