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In vivo andin vitro tests in anaphylactic reactions to anaesthetic agents

Agents and Actions volume 33, pages 208–211 (1991)Cite this article

Abstract

The majority of patients with anaphylactoid reactions (AR) under general anaesthesia showed histamine release from basophil leucocytes (HRL) by neuromuscular blockersin vitro (none in normals) and high levels of serum IgE antibody (detected by the ‘new’ paper radioallergosorbent test, RAST; little or none in normals) which reacted with the quaternary ammonium group of choline, and less frequently of alcuronium, strongly suggesting that IgE antibody, HRL and AR are related. Skin tests on their own are of limited value.

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References

  1. J. Watkins,Investigation of allergic and hypersensitivity reactions to anaesthetic agents. Br. J. Anaesth.59, 104–111 (1987).

    PubMed  Google Scholar 

  2. W. Lorenz, A. Doenicke, B. Schoning and E. Neugebaur,The role of histamine in adverse reactions to intravenous agents. InAdverse reactions of anaesthetic drugs. pp. 169–238 (Ed. J. A. Thornton). Elsevier, Amsterdam 1981.

    Google Scholar 

  3. E. S. K. Assem and B. Y. Ling,Fatal anaphylactic reaction to suxamethonium: new screening test suggests possible prevention. Anaesthesia43, 958–961 (1988).

    PubMed  Google Scholar 

  4. E. S. K. Assem,Examples of the correlation between the structure of certain groups of drugs and adverse effects mediated by immune and non-immune mechanisms (with particular reference to muscle relaxants and steroid anaesthetics. InDrug design and adverse reactions. pp. 209–229 (Eds. H. Bundgaard, P. Juul and H. Kofod). Munksgaard, Copenhagen 1977.

    Google Scholar 

  5. E. S. K. Assem,Reaction to neuromuscular blocking drugs. InAllergic reactions to drugs. Handbook of experimental pharmacology. Vol. 63, pp. 299–312 (Eds. A. DeWeck and H. Bundgaard). Springer, Heidelberg, 1983.

    Google Scholar 

  6. E. S. K. Assem,Anaphylactic anaesthetic reactions: value of paper allergosorbent test for IgE antibodies to muscle relaxants and thiopentone. Anaesthesia45, 1032–1038 (1990).

    PubMed  Google Scholar 

  7. E. S. K. Assem,Characteristics of basophil histamine release by neuromuscular blocking drugs in patients with anaphylactoid reactions. Agents and Actions14, 435–440 (1984).

    PubMed  Google Scholar 

  8. E. S. K. Assem, P. G. Frost and R. D. Levis,Anaphylactic-like reaction to suxamethonium. Anaesthesia36, 405–410 (1981).

    PubMed  Google Scholar 

  9. E. S. K. Assem and I. E. Symons,Anaphylaxis due to suxamethonium in a seven year old child: a 14 year follow-up with allergy testing. Anaesthesia44, 121–124 (1989).

    PubMed  Google Scholar 

  10. B. A. Baldo and M. M. Fisher,Substituted ammonium ions as allergenic determinants in drug allergy. Nature306, 262–264 (1983).

    PubMed  Google Scholar 

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  1. Department of Pharmacology, University College London and University College Hospital, Gower Street, WC1, London, UK

    E. S. K. Assem

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  1. E. S. K. Assem
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Assem, E.S.K. In vivo andin vitro tests in anaphylactic reactions to anaesthetic agents. Agents and Actions 33, 208–211 (1991). https://doi.org/10.1007/BF01993169

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  • DOI: https://doi.org/10.1007/BF01993169

Keywords

  • Ammonium
  • Histamine
  • General Anaesthesia
  • Choline
  • Skin Test