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, Volume 33, Issue 1–2, pp 197–199 | Cite as

Vascular responses to histamine at low temperatures in normal digital skin and Raynaud's phenomenon

  • C. B. Bunker
  • J. C. Foreman
  • P. M. Dowd
Histamine and Clinical Studies

Abstract

A defective histaminergic dilating system in the digital vasculature has been proposed for the pathophysiology of Raynaud's phenomenon but this is not supported by studies of digital intradermal responses to histamine or agents which cause histamine release. The vascular responses (measured by planimetry and laser Doppler flowmetry) of digital skin over the middle phalanx to intradermal histamine, compound 48/80 and Substance P have now been studied at low temperatures (because it is in the cold that Raynaud's phenomenon occurs) in normal controls and patients with primary Raynaud's phenomenon. A cold-related attenuation of mast cell histamine release by compound 48/80 was observed in both normal and Raynaud's subjects. These results do not support a major histaminergic defect in the pathogenesis of Raynaud's phenomenon.

Keywords

Mast Cell Histamine Normal Control Histamine Release Vascular Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • C. B. Bunker
    • 1
  • J. C. Foreman
    • 2
  • P. M. Dowd
    • 1
  1. 1.Department of DermatologyThe Middlesex HospitalLondonUK
  2. 2.Department of Pharmacology, University College and Middlesex School of MedicineUniversity CollegeLondonUK

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