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Distribution of histamine in developing rat tissues

  • Histamine Receptors, Distribution and Metabolism
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Abstract

An antiserum against conjugated histamine was used to reveal the location and time of the appearance of the amine in different organs during the development of fetal and early postnatal rats. Tissues were fixed in 4% 1-ethyl-3(3-dimethyl-aminopropyl) carbodiimide and standard indirect immunofluorescence technique was used.

Histamine-immunoreactivity (HA-ir) was first detected in the rat fetus on the 10th embryonic day (day E10) in the embryonic liver. The liver remained immunoreactive during the second half of the fetal life. In addition to some small HA-ir cells in the stomach wall and in the kidneys on day E16, the papillary muscles of the fetal heart also exhibited patchy immunofluorescence at this stage. On day E18, HA-ir cells appeared in many other organs including lungs, gastric mucosa and smooth muscle cells of the stomach wall, heart muscle and subcutaneous tissue. The distribution of HA-ir in fetal tissues was most extensive on day E20 when the kidney tubules and the skin also exhibited bright fluorescence.

These results suggest that histamine is widely distributed during fetal development in different cell types.

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References

  1. G. Kahlson and E. Rosengren,New approaches to the physiology of histamine. Physiol. Rev.48 155–196 (1968).

    PubMed  Google Scholar 

  2. G. Kahlson, K. Nilsson, E. Rosengren and B. Zederfeldt,Wound healing as dependent on rate of histamine formation. Lancet279, 230–234 (1969).

    Google Scholar 

  3. G. Kahlson and E. Rosengren.Inhibition of histamine formation and some of its consequences. J. Physiol.149, 66p (1959).

    Google Scholar 

  4. B. C. Tilly, L. G. J. Tertoolen, R. Remorie, A. Ladoux, I. Varlaan, S. W. deLaat and W. H. Moolenaar,Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: action through Ca ++-mobilizing H 1 receptors. J. Cell Biol.110, 1211–1215 (1990).

    PubMed  Google Scholar 

  5. G. Kahlson, E. Rosengren and T. White,The formation of histamine in the rat fetus. J. Physiol.151, 131–138 (1960).

    PubMed  Google Scholar 

  6. P. Panula, H. Y.-T. Yang and E. Costa,Histamine-containing neurons in the rat hypothalamus. Proc. Natl. Acad. Sci.81, 2572–2576 (1984).

    PubMed  Google Scholar 

  7. S. Auvinen and P. Panula,Development of histamine-immunoreactive neurons in the rat brain. J. Comp. Neur.276, 289–303 (1988).

    PubMed  Google Scholar 

  8. G. Kahlson, E. Rosengren and T. White,Formation of histamine by the fetus in the rat and man. J. Physiol.145, 30–31P (1959).

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy, University of Helsinki, Siltavuorenpenger 20 a, SF-00170, Helsinki, Finland

    M. J. Nissinen & P. Panula

Authors
  1. M. J. Nissinen
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  2. P. Panula
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Nissinen, M.J., Panula, P. Distribution of histamine in developing rat tissues. Agents and Actions 33, 177–180 (1991). https://doi.org/10.1007/BF01993160

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  • DOI: https://doi.org/10.1007/BF01993160

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