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, Volume 33, Issue 1–2, pp 150–153 | Cite as

Liver damage, voluntary alcohol intake and brain histamine

  • W. A. Fogel
  • W. Andrzejewski
  • C. Maslinski
Histamine and the Nervous System


Liver dysfunction induced by portocaval anastomosis (PCA) in the rat is associated with a great reduction of hepatic alcohol and aldehyde dehydrogenase activities. Despite this, PCA rats voluntarily drank more alcohol than unoperated rats. When subjected to forced alcohol consumption, shunted rats maintained their exaggerated voluntary alcohol intake whereas unoperated rats developed aversion to alcohol. Hypothalamic levels of both histamine and histidine were very high in PCA rats. When these rats were chronically exposed to alcohol, there was a slight decrease in hypothalamic histidine concentration and consequently a lower histamine content. Chronic exposure to alcohol did not, however, influence hypothalamic tissue levels of histamine or histidine in unoperated rats. In both groups, chronic alcohol treatment exerted a stimulatory effect on hepatic alcohol metabolizing enzymes.


Histamine Histidine Aldehyde Dehydrogenase Chronic Alcohol Alcohol Treatment 
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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • W. A. Fogel
    • 1
  • W. Andrzejewski
    • 2
  • C. Maslinski
    • 1
  1. 1.Department of Biogenic AminesPolish Academy of SciencesLodzPoland
  2. 2.Department of SurgeryJ. Brudzinski Memorial City HospitalLodzPoland

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