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Comparative activity of the new fluoroquinolone bay y3118 against 177 penicillin susceptible and resistant pneumococci

  • New Antimicrobial Agent
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Abstract

The activity of a new fluoroquinolone, Bay y3118, was evaluated in comparison to three quinolones (ciprofloxacin, ofloxacin, lomefloxacin) and four broad-spectrum oral cephalosporins (cefpodoxime, cefuroxime, cefaclor, cefixime) against 49 penicillin-susceptible pneumococci, 77 pneumococci with intermediate resistance and 51 penicillin-resistant pneumococci. Quinolone activity was not affected by the penicillin susceptibility status of the organisms. Bay y3118 was very active against all strains, with an MIC90 of 0.015 µg/ml. Other quinolones were less active, with MIC90s of 4 µg/ml (ciprofloxacin and ofloxacin) and 8 µg/ml (lomefloxacin). Cephalosporin MICs rose parallel to those of penicillin. Cefuroxime and cefpodoxime were the most active cephalosporins, with MIC90s for strains showing susceptibility, intermediate resistance and resistance of 0.125–0.25, 2–4 and 4 µg/ml, respectively. Cefaclor and cefixime were less active, with corresponding MIC90s of 1–2, 8–16 and > 16 µg/ml, respectively.

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Authors and Affiliations

  1. Department of Pathology, Hershey Medical Center, PO Box 850, 17033, Hershey, Pennsylvania, USA

    S. K. Spangler & P. C. Appelbaum

  2. Department of Pathology, Case Western Reserve University, 44106, Cleveland, Ohio, USA

    M. R. Jacobs

Authors
  1. S. K. Spangler
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  2. M. R. Jacobs
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  3. P. C. Appelbaum
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Spangler, S.K., Jacobs, M.R. & Appelbaum, P.C. Comparative activity of the new fluoroquinolone bay y3118 against 177 penicillin susceptible and resistant pneumococci. Eur. J. Clin. Microbiol. Infect. Dis. 12, 965–967 (1993). https://doi.org/10.1007/BF01992176

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  • DOI: https://doi.org/10.1007/BF01992176

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