European Journal of Pediatrics

, Volume 154, Issue 2, pp 157–160 | Cite as

Specific decrease of anti-pseudomonal IgA after anti-pseudomonal therapy in cystic fibrosis

  • K. de Boeck
  • E. Eggermont
  • M. Smet
  • P. van Reempts
  • H. P. van Bever
  • W. J. Stevens
Pneumology Original Paper


In patients with cystic fibrosis (CF) and chronic colonisation withPseudomonas aeruginosa, specific anti-pseudomonal IgG and IgA, as well as serum immunoreactive protein C, WBC and differential count, ESR, pulmonary function and chest radiograph score were determined before and after a 2 week intravenous course of anti-pseudomonal antibiotics in 32 cases of acute exacerbation of pulmonary infection. Specific anti-pseudomonal IgA but not specific anti-pseudomonal IgG decreased significantly after treatment. Log of anti-pseudomonal IgA but not log anti-pseudomonal IgG correlated well with disease severity as assessed by the Brasfield chest radiograph score (r 0.57), forced expiratory volume in 1 s (r 0.6) as well as C-reactive protein (r 0.62).

Key words

Cystic fibrosis Pseudomonas aeruginosa IgA antibodies IgG antibodies 



cystic fibrosis


forced expiratory volume in 1 s


Pseudomonas aeruginosa


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • K. de Boeck
    • 1
  • E. Eggermont
    • 1
  • M. Smet
    • 1
  • P. van Reempts
    • 2
  • H. P. van Bever
    • 2
  • W. J. Stevens
    • 2
  1. 1.Department of PaediatricsUniversity Hospital of LeuvenLeuvenBelgium
  2. 2.Department of ImmunologyUniversity Hospital of AntwerpBelgium

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