European Journal of Pediatrics

, Volume 154, Issue 2, pp 157–160 | Cite as

Specific decrease of anti-pseudomonal IgA after anti-pseudomonal therapy in cystic fibrosis

  • K. de Boeck
  • E. Eggermont
  • M. Smet
  • P. van Reempts
  • H. P. van Bever
  • W. J. Stevens
Pneumology Original Paper

Abstract

In patients with cystic fibrosis (CF) and chronic colonisation withPseudomonas aeruginosa, specific anti-pseudomonal IgG and IgA, as well as serum immunoreactive protein C, WBC and differential count, ESR, pulmonary function and chest radiograph score were determined before and after a 2 week intravenous course of anti-pseudomonal antibiotics in 32 cases of acute exacerbation of pulmonary infection. Specific anti-pseudomonal IgA but not specific anti-pseudomonal IgG decreased significantly after treatment. Log of anti-pseudomonal IgA but not log anti-pseudomonal IgG correlated well with disease severity as assessed by the Brasfield chest radiograph score (r 0.57), forced expiratory volume in 1 s (r 0.6) as well as C-reactive protein (r 0.62).

Key words

Cystic fibrosis Pseudomonas aeruginosa IgA antibodies IgG antibodies 

Abbreviations

CF

cystic fibrosis

FEV1

forced expiratory volume in 1 s

Pa

Pseudomonas aeruginosa

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Baltimore RS, Christie CDC, Walker Smith GJ (1989) Immunohistopathologic localization ofPseudomonas aeruginosa in lungs from patients with cystic fibrosis. Am Rev Respir Dis 140: 1650–1661PubMedGoogle Scholar
  2. 2.
    Brasfield D, Hicks G, Soong SJ, Tiller RE (1979) The chest radiogram in cystic fibrosis: a new scoring system. Pediatrics 63: 24–29PubMedGoogle Scholar
  3. 3.
    Brett MM, Ghoneim ATM, Littlewood JM (1986) Serum antibodies toPseudomonas aeruginosa in patients with cystic fibrosis. Arch Dis Child 61: 1114–1120PubMedGoogle Scholar
  4. 4.
    Brett MM, Ghoneim ATM, Littlewood JM (1990) Serum IgA antibodies againstPseudomonas aeruginosa in patients with cystic fibrosis. Arch Dis Child 65: 259–263PubMedGoogle Scholar
  5. 5.
    Brett MM, Simmonds EJ, Ghoneim ATM, Littlewood JM (1992) The value of serum IgG titres againstPseudomonas aeruginosa in the management of early pseudomonal infection in cystic fibrosis. Arch Dis Child 67: 1086–1088PubMedGoogle Scholar
  6. 6.
    Cordon SM, Elborn JS, Rayner RJ, Hiller EJ, Shale DJ (1992) IgG antibodies in earlyPseudomonas aeruginosa infection in cystic fibrosis. Arch Dis Child 67: 737–740PubMedGoogle Scholar
  7. 7.
    Corey M, Levison H, Crosier D (1976) Five to seven year course of pulmonary function in cystic fibrosis. Am Rev Respir Dis 114: 1085–1092PubMedGoogle Scholar
  8. 8.
    Gibson LE, Cooke RE (1959) A test for the concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilising pilocarpine by iontophoresis. Pediatrics 23: 545–5PubMedGoogle Scholar
  9. 9.
    Glass S, Hayward C, Govan JRW (1988) Serum C-reactive protein in assessment of pulmonary exacerbation and anti-microbial therapy in cystic fibrosis. J Pediatr 113: 76–79PubMedGoogle Scholar
  10. 10.
    Mearns MB, Hunt GH, Rushwort R (1972) Bacterial flora of respiratory tract in patients with cystic fibrosis, 1950–1971. Arch Dis Child 47: 902–907PubMedGoogle Scholar
  11. 11.
    Pedersen SS, Espersen F, Hoiby N (1987) Diagnosis of chronicPseudomonas aeruginosa in patients with cystic fibrosis by enzyme linked immunosorbent assay. J Clin Microbiol 25: 1830–1836PubMedGoogle Scholar
  12. 12.
    Schiotz PO (1981) Local humoral immunity and immune reactions in the lungs of patients with cystic fibrosis. Acta Pathol Microbiol Immunol Scand [Suppl] 276: 1–11Google Scholar
  13. 13.
    Van Bever HP, Gigase PL, De Clerck LS, Bridts CH, Franckx H, Stevens WJ (1988) Immune complexes andPseudomonas aeruginosa antibodies in cystic fibrosis. Arch Dis Child 63: 1222–1228PubMedGoogle Scholar
  14. 14.
    Winnie GB, Cowan RG (1991) Respiratory tract colonisation withPseudomonas aeruginosa in cystic fibrosis: correlations between anti-Pseudomonas aeruginosa antibody levels and pulmonary function. Pediatr Pulmonol 10: 92–100PubMedGoogle Scholar
  15. 15.
    Zapletal A, Samawek M, Paul T (1987) Lung function in children and adolescents. Methods and reference values. Karger, MunchenGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • K. de Boeck
    • 1
  • E. Eggermont
    • 1
  • M. Smet
    • 1
  • P. van Reempts
    • 2
  • H. P. van Bever
    • 2
  • W. J. Stevens
    • 2
  1. 1.Department of PaediatricsUniversity Hospital of LeuvenLeuvenBelgium
  2. 2.Department of ImmunologyUniversity Hospital of AntwerpBelgium

Personalised recommendations