, Volume 37, Issue 3, pp 308–310 | Cite as

Studies on muscle fibre splitting in skeletal muscle

  • G. W. Atherton
  • N. T. James
  • M. Mahon


Autoradiographic, stereological and histological studies have been carried out to determine the origin of muscle fibre splitting which supposedly occurs during muscle hypertrophy. The results obtained clearly indicate that the supposedly ‘split fibres’ are a transient response probably derived from satellite cells and are not derived from pre-existing fibres by true splitting. Similarly, increases in muscle fibre size are not achieved by recruitment of satellite structures as indicated by lack of myonuclear recruitment.


Skeletal Muscle Muscle Fibre Satellite Cell Histological Study Transient Response 
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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • G. W. Atherton
    • 1
    • 2
  • N. T. James
    • 1
    • 2
  • M. Mahon
    • 1
    • 2
  1. 1.Department of Human Biology and AnatomyUniversity of SheffieldSheffield(England)
  2. 2.Department of AnatomyUniversity of ManchesterManchester(England)

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