Experientia

, Volume 37, Issue 3, pp 292–293 | Cite as

Effects of dihydroergocriptine on mouse and rat resistance to acute anoxia: influence of repetition of treatment

  • J. M. Legeai
  • M. M. Benharkate
  • J. -P. Duverger
  • R. G. Boulu
Specialia

Summary

The antihypoxic activity of DHEC mesylate, as evaluated in mice and rats submitted to hypobaric hypoxia and to asphyxic anoxia respectively, is noticeably stronger when the compound is administered according to a repeated treatment schedule than when administered only once. The results correlate well with human clinical observations.

Keywords

Clinical Observation Mesylate Treatment Schedule Repeated Treatment Hypobaric Hypoxia 

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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • J. M. Legeai
    • 1
    • 2
  • M. M. Benharkate
    • 1
    • 2
  • J. -P. Duverger
    • 1
    • 2
  • R. G. Boulu
    • 1
    • 2
  1. 1.Centre de Recherches des Laboratoires Jacques LogeaisTrappes-Elancourt(France)
  2. 2.U.E.R. Mécanismes d'Action des Médicaments et des ToxiquesUniversité René-DescartesParis(France)

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