, Volume 37, Issue 3, pp 224–226 | Cite as

Sequential changes in serum glucose, triglycerides and cholesterol in aging of normal and alloxan-diabetic rats

  • B. M. Altura
  • G. Lum
  • P. D. M. V. Turlapaty
  • Bella T. Altura


16-week-old Wistar, alloxan diabetic rats exhibited progressive elevations in levels of serum glucose, total triglycerides, cholesterol and creatinine over a period of 8 weeks; hyperglycemia preceeded hyperlipidemia and hypercreatininemia and hypertriglyceridemia preceeded hypercholesteremia. Age-matched control rats failed to develop any signs of hyperglycemia or hypercreatininemia, but did develop both hypercholesterolemia and hypertriglyceridemia at 24 weeks of age. This suggests that the progressive cardiovascular derangements (e.g., atherosclerosis, hypertension) noted in experimental diabetes mellitus and in the normal aging (and maturation) process may be brought about by distinctly different biochemical processes.


Cholesterol Diabetes Mellitus Atherosclerosis Creatinine Triglyceride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 2.
    P. White, Diabetes5, 445 (1956).PubMedGoogle Scholar
  2. 3.
    K.W. Walton, in, The Biological Basis of Medicine, vol. 6, p. 193. Ed. E.E. Bittar and E. Bittar. Academic Press, New York 1969.Google Scholar
  3. 4.
    A.R. Christlieb, Am. J. Cardiol.32, 596 (1973).Google Scholar
  4. 5.
    P.C. Scott, Am. Heart J.90, 283 (1975).PubMedGoogle Scholar
  5. 6.
    B.M. Altura and B.T. Altura, in: Factors Influencing Vascular Reactivity, p. 169. Ed. O. Carrier, Jr, and S. Shibata. Igaku-Shoin Ltd, Tokyo 1977.Google Scholar
  6. 7.
    D.E. McMillan, Am. Heart J.96, 401 (1978).PubMedGoogle Scholar
  7. 8.
    K.M. West, Epidemiology of Diabetes and Its Vascular Lesions. Elsevier, New York 1978.Google Scholar
  8. 9.
    P. Petrides, L. Weiss, G. Löffler and O.H. Wieland, Diabetes Mellitus: Theory and Management, Urban & Schwarzenberg. Baltimore 1978.Google Scholar
  9. 10.
    T.A. Cavaliere and D.G. Taylor, Fedn Proc.37, 490 (1978).Google Scholar
  10. 11.
    P.D.M.V. Turlapaty, G. Lum and B.M. Altura, Fedn Proc.39, part 2, 635 (1980).Google Scholar
  11. 12.
    P. Trinder, Ann. clin. Biochem.6, 24 (1969).Google Scholar
  12. 13.
    C.C. Allain, L.S. Poon, C.S.G. Chan, N. Richmond and P.C. Fu, Clin. Chem.20, 470 (1974).PubMedGoogle Scholar
  13. 14.
    G. Buccolo and H. David, Clin. Chem.19, 476 (1973).PubMedGoogle Scholar
  14. 15.
    D.L. Fabiny and G. Ertingshausen, Clin. Chem.17, 696 (1971).PubMedGoogle Scholar
  15. 16.
    B. Wexler, Atherosclerosis34, 277 (1979).PubMedGoogle Scholar
  16. 17.
    Y. Hashimoto, Jap. Circulation J.33, 1315 (1969).Google Scholar
  17. 18.
    N. Kalant, J.L. Teitelbaum, A.A. Cooperberg and W.A. Harland, J. Lab. clin. Med.63, 147 (1964).PubMedGoogle Scholar
  18. 19.
    S.G. Lams and B.C. Wexler, Br. J. exp. Path58, 177 (1977).Google Scholar
  19. 20.
    F.D.W. Lukens, Physiol. Rev.28, 304 (1948).Google Scholar
  20. 21.
    W.E. Dulin and M.G. Soret, in: The Diabetic Pancreas, p. 434. Ed. B.W. Volk and K.F. Wellmann. Plenum Press, New York 1977.Google Scholar
  21. 22.
    L.A. Carlson, S.O. Fröberg and E.R. Nye, Gerontologia14, 65 (1968).Google Scholar
  22. 23.
    H. Kawashima, T. Igarashi, Y. Nakajma, V. Akiyama, K. Usuki and S. Ohtake, Naunyn-Schmiedebergs Arch. Pharmak.305 123 (1978).Google Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • B. M. Altura
    • 1
  • G. Lum
    • 1
  • P. D. M. V. Turlapaty
    • 1
  • Bella T. Altura
    • 1
  1. 1.Department of Physiology and Pathology, State University of New YorkDownstate Medical CenterBrooklynUSA

Personalised recommendations