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Experientia

, Volume 37, Issue 3, pp 224–226 | Cite as

Sequential changes in serum glucose, triglycerides and cholesterol in aging of normal and alloxan-diabetic rats

  • B. M. Altura
  • G. Lum
  • P. D. M. V. Turlapaty
  • Bella T. Altura
Specialia

Summary

16-week-old Wistar, alloxan diabetic rats exhibited progressive elevations in levels of serum glucose, total triglycerides, cholesterol and creatinine over a period of 8 weeks; hyperglycemia preceeded hyperlipidemia and hypercreatininemia and hypertriglyceridemia preceeded hypercholesteremia. Age-matched control rats failed to develop any signs of hyperglycemia or hypercreatininemia, but did develop both hypercholesterolemia and hypertriglyceridemia at 24 weeks of age. This suggests that the progressive cardiovascular derangements (e.g., atherosclerosis, hypertension) noted in experimental diabetes mellitus and in the normal aging (and maturation) process may be brought about by distinctly different biochemical processes.

Keywords

Cholesterol Diabetes Mellitus Atherosclerosis Creatinine Triglyceride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • B. M. Altura
    • 1
  • G. Lum
    • 1
  • P. D. M. V. Turlapaty
    • 1
  • Bella T. Altura
    • 1
  1. 1.Department of Physiology and Pathology, State University of New YorkDownstate Medical CenterBrooklynUSA

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