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Influence of metiamide and atropine on acid and pepsin secretion in the anaesthetized Heidenhain cat

Agents and Actions volume 11, pages 164–167 (1981)Cite this article

Abstract

The inhibition of acid and pepsin secretion by metiamide and atropine was studied in the anaesthetized Heidenhain-pouch cat.

Metiamide strongly inhibited acid secretion induced by histamine, pentagastrin or carbachol. Metiamide had no effect on pepsin secretion stimulated by pentagastrin and carbachol but was effective on histamine-stimulated pepsin secretion. Atropine strongly inhibited pepsin secretion but was not as effective as metiamide in the inhibition of acid secretion.

Reperfusion of the pouch with acid+salicylic acid also increased pepsin secretion. This increased pepsin output was abolished by atropine, but not by metiamide.

It is postulated that (1) the peptic cell probably has only cholinergic receptors which can be additionally triggered by HCl passing the peptic cell, and (2) H2-antagonists only inhibit pepsin secretion indirectly via reduction of acid output.

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References

  1. L.R. Johnson,Pepsin Stimulated by Topical Hydrochloric and Acetic Acids, Gastroenterology62, 33–38 (1972).

    PubMed  Google Scholar 

  2. L.R. Johnson,Regulation of Pepsin Secretion by Topical Acid in the Stomach, Am. J. Physiol.223, 847–850 (1972).

    PubMed  Google Scholar 

  3. I. Szelenyi andK. Thiemer,Influence of Metiamide and Atropine on Pepsinogen Secretion in the Conscious Rat, Experientia33, 1620–1621 (1977).

    PubMed  Google Scholar 

  4. H. Engler andE. Fritschi,Methode zur kontinuierlichen Bestimmung der Säuresekretion bei narkotisierten Katzen, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.297, R 54.

  5. P.K. Debnath, K.D. Gode, D.G. Das andA.K. Sanyal,Effects of Propranolol on Gastric Secretion in Albino Rats, Br. J. Pharmac.51, 213–216 (1974).

    Google Scholar 

  6. Cavalli-sforza,Biometrie (Fischer-Verlag, Stuttgart 1974).

    Google Scholar 

  7. I. Szelenyi andH. Engler,The Effect of Atropine and Metiamide on Pepsin Secretion of the Rat Agents and Actions (in press).

  8. K.T. Bunce, M.E. Parsons andF.R. Matheson,Inhibition of Pepsin Secretion by Metiamide and Atropine in the Conscious Rat, Agents and Actions9, 163–167 (1979).

    PubMed  Google Scholar 

  9. S.J. Konturek, T. Radecki, T. Demitrescu andA. Dembinski,Comparison of Effects of Metiamide and Atropine on Gastric and Pancreatic Secretion and Pepsin Ulcer Formation in Cat, Digestion10, 267–281 (1974).

    PubMed  Google Scholar 

  10. M. Albinus, E.L. Blair, B.H. Hirst, D.J. Reed, A.U. Schally andB. Shaw,The Effects of Somatostatin and Metiamide on Tachyphylaxis of Pentagastrin Stimulated Gastric Acid and Pepsin Secretion in the Conscious Cat, J. Physiol. (Lond.)266, 801–817 (1977).

    Google Scholar 

  11. E.S. Vizi, G. Bertaccini, M. Impicciatore andJ. Knoll,Acetylcholine-Releasing Effect of Gastrin and Related Polypeptides, Eur. J. Pharmac.17, 175–178 (1972).

    Google Scholar 

  12. L.R. Johnson,Pepsin Stimulated by Topical Hydrochloric and Acetic Acids, Gastroenterology62, 33–38 (1972).

    PubMed  Google Scholar 

  13. L.R. Johnson,Pepsin Secretion During Damage by Ethanol and Salicylic Acid, Gastroenterology,62, 412–416 (1972).

    PubMed  Google Scholar 

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Affiliations

  1. Department of Pharmacology, Heumann-Pharma, Heideloffstrasse 18-28, D-85, Nürnberg, Federal Republic of Germany

    H. Engler, H. Beck & I. Szelenyi

Authors
  1. H. Engler
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  2. H. Beck
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  3. I. Szelenyi
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Engler, H., Beck, H. & Szelenyi, I. Influence of metiamide and atropine on acid and pepsin secretion in the anaesthetized Heidenhain cat. Agents and Actions 11, 164–167 (1981). https://doi.org/10.1007/BF01991490

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  • DOI: https://doi.org/10.1007/BF01991490

Keywords

  • Histamine
  • Salicylic Acid
  • Atropine
  • Acid Secretion
  • Carbachol