Abstract
After inactivation of the fast sodium channels by partial depolarization (25 mmol/l K+ Tyrode solution) histamine (10−6–10−5 mol/l) restored the electrical and mechanical activity in isolated electrically paced left auricle of rabbit. Transmembrane action potentials restored by histamine in this condition have a nearly normal height of overshoot with a low resting potential and with a very low rate of rise. The AP-restoring effect of histamine was affected neither by beta-adrenergic blocking agent, Pindolol (4×10−7 mol/l) nor H2-receptor antagonist, cimetidine (2×20−6 mol/l) but was antagonized by H1-receptor blocker, mepyramine (10−5 mol/l) and by the selective Ca+2-channel blocker, D-600 (2×10−6 mol/l). The results suggest that in this species histamine may stimulate the slow inward Ca2+ current mediated by H1-receptors.
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References
D. Reinhardt, J. Wagner andH.J. Schumann,Differentiation of H 1 - and H 2 -Receptors Mediating Positive Chrono- and Inotropic Responses to Histamine on Atrial Preparations of the Guinea-pig, Agents and Actions4, 217–221 (1974).
S.C. Verma andJ.H. McNeill,Cardiac Histamine Receptors: Differences between Left and Right Atria and Right Ventricle, J. Pharmac. exp. Ther. 200–362 (1977).
F. Ledda, L. Mantelli andL. Mugelli,Blockage by Burimamide of the Restorative Effect of Histamine in Tetrodotoxin Treated Heart Preparations, Br. J. Pharmac.57, 247–249 (1976).
J. Inui andH. Imamura,Restoration by Histamine of the Calcium-Dependent Electrical and Mechanical Response in the Guinea-Pig Papillary Muscle Partially Depolarized by Potassium, Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.294, 261–269 (1976).
V. Kecskeméti,Restorative Effect of Histamine on the Transmembrane Action Potentials in Potassium-Depolarized Guinea-Pig Auricle, Pol. J. Pharmac. Pharm.30, 377–386 (1978).
V. Kecskeméti, K. Kelemen andJ. Knoll,Effect of Prostaglandin E 1 on the Cardiac Transmembrane Potentials, Eur. J. Pharmac.24, 289–295 (1973).
V. Kecskeméti, K. Kelemen andJ. Knoll,Comparative Effects of Prostaglandin F 2α and A 2 on the Cardiac Transmembrane Potentials, Acta biol. med. Germ.37, 821–824 (1978).
A.J. Pappano,Calcium-Dependent Action Potentials Produced by Catecholamines in Guinea Pig Atrial Muscle Fibers Depolarized by Potassium, Circ. Res.27, 379–390 (1970).
E. Coraboeuf,Ionic Basic of Electrical Activity in Cardiac Tissues, Am. J. Physiol.234, H101-H116 (1978).
G.W. Beeler andH. Reuter,Reconstruction of the Action Potential of Ventricular Myocardial Fibres, J. Physiol. (Lond.) 177–210 (1977).
P.T. Thyrum,Inotropic Stimuli and Systolic Transmembrane Calcium Flow in Depolarized Guinea-pig Atria, J. Pharmac. exp. Ther.188, 166–179 (1974).
O. Rougier, G. Vassort, D. Garnier, Y.M. Gargouil andE. Coraboeuf,Existence and Role of a slow Inward Current during the Frog Atrial Action Potential, Pflügers Arch.308, 91–110 (1969).
M. Kohlhardt, B. Bauer, H. Krause andA. Fleckenstein,Differentiation of the Transmembrane Na and Ca Channels in Mammalian Cardiac Fibres by the Use of Specific Inhibitors, Pflügers Arch.335, 309–322 (1972).
Sh. Chiba,Blocking Effect of Tripelennamine on Histamine-Induced Positive Chronotropic and Inotropic Responses of the Dog Atrium, Tokoku J. Exp. Med.120, 299–300 (1976).
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Kecskeméti, V. Effects of H1- and H2-receptor antagonists on calcium-dependent action potentials produced by histamine in rabbit left auricles depolarized by potassium. Agents and Actions 11, 114–116 (1981). https://doi.org/10.1007/BF01991476
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DOI: https://doi.org/10.1007/BF01991476