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Agents and Actions

, Volume 36, Issue 1–2, pp 152–158 | Cite as

Zinc monoglycerolate — A slow-release source of therapeutic zinc: Solubilization by endogenous ligands

  • D. P. Fairlie
  • M. W. Whitehouse
  • R. M. Taylor
Inflammation and Immunomodulation

Abstract

A combination of65Zn-tracer determinations, oxidative analyses for glycerol, and a bioassay for uncomplexed Zn2+ have shown that: (i) zinc monoglycerolate (ZMG) dissolves in aqueous salt dissolutions/physiological media by dissociation into zinc ions and glycerol, but the rate and extent of ZMG dissolution depend upon pH, and/or concentration and complexing efficiency of zinc-ligands; (ii) under physiological conditions certain ligands present in skin and blood (e.g. citrate, lactate, albumin, histidine, glutathione and other thiols and, to a lesser extent, amino acids) accelerate ZMG dissolution; and (iii) there is a general correlation between the conditional stability constants (pH 7.3, 25°C) of zinc-ligand complexes and the ability of given ligands to (a) solubilize ZMGin vitro and (b) mask the irritancy of Zn2+in vivo. These observations indicate a mechanism for the transformation of ZMG applied transdermally or subcutaneously, to bioactive zinc (anti-arthritic nutritional supplement, etc.).

Keywords

Zinc Glycerol Albumin Lactate Glutathione 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BSA

Bovine serum albumin

Hepes

N-[2-Hydroxyethyl] piperazine-N1[2-ethanesulfonic acid]

JCPDS

Joint Committe of Powder Diffraction Studies (USA)

Mes

2-[N-Morpholino] ethanesulfonic acid

Pipes

Piperazine-N,N1 bis[2-ethanesulfonic acid]

ZMG

Zinc monoglycerolate

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • D. P. Fairlie
    • 1
  • M. W. Whitehouse
    • 1
  • R. M. Taylor
    • 2
  1. 1.Department of PathologyUniversity of AdelaideAdelaide
  2. 2.CSIRO Division of SoilsUrrbrae

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