Agents and Actions

, Volume 36, Issue 1–2, pp 152–158 | Cite as

Zinc monoglycerolate — A slow-release source of therapeutic zinc: Solubilization by endogenous ligands

  • D. P. Fairlie
  • M. W. Whitehouse
  • R. M. Taylor
Inflammation and Immunomodulation


A combination of65Zn-tracer determinations, oxidative analyses for glycerol, and a bioassay for uncomplexed Zn2+ have shown that: (i) zinc monoglycerolate (ZMG) dissolves in aqueous salt dissolutions/physiological media by dissociation into zinc ions and glycerol, but the rate and extent of ZMG dissolution depend upon pH, and/or concentration and complexing efficiency of zinc-ligands; (ii) under physiological conditions certain ligands present in skin and blood (e.g. citrate, lactate, albumin, histidine, glutathione and other thiols and, to a lesser extent, amino acids) accelerate ZMG dissolution; and (iii) there is a general correlation between the conditional stability constants (pH 7.3, 25°C) of zinc-ligand complexes and the ability of given ligands to (a) solubilize ZMGin vitro and (b) mask the irritancy of Zn2+in vivo. These observations indicate a mechanism for the transformation of ZMG applied transdermally or subcutaneously, to bioactive zinc (anti-arthritic nutritional supplement, etc.).


Zinc Glycerol Albumin Lactate Glutathione 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Bovine serum albumin


N-[2-Hydroxyethyl] piperazine-N1[2-ethanesulfonic acid]


Joint Committe of Powder Diffraction Studies (USA)


2-[N-Morpholino] ethanesulfonic acid


Piperazine-N,N1 bis[2-ethanesulfonic acid]


Zinc monoglycerolate


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  1. [1]
    E. W. Radoslovich, M. Raupach, P. G. Slade and R. M. Taylor,Crystalline cobalt, zinc manganese and iron alkoxides of glycerol. Aust. J. Chem.23, 1963–1971 (1970).Google Scholar
  2. [2]
    T. W. Hambley and M. R. Snow,The crystal and molecular structure of zinc(II) monoglycerolate. Aust. J. Chem.36, 1249–1253 (1983).Google Scholar
  3. [3]
    R. M. Taylor and A. J. Brock,Pharmaceutical compound and method. U.K. Patent, 2101132B, 1980; Aust Patent, PCT Au86/00251, 1986.Google Scholar
  4. [4]
    K. D. Rainsford and M. W. Whitehouse,Anti-ulcer activity of zinc monoglycerolate (Glyzinc R ) a slow-release zinc formulation. Clin. Exp. Pharmacol. Physiol.12 (Suppl), 119 (1988).Google Scholar
  5. [5]
    M. W. Whitehouse, K. D. Rainsford, R. M. Taylor and B. Vernon-Roberts,Zinc monoglycerolate: a slow-release source of zinc with anti-arthritic activity in rats. Agents and Actions31, 47–58 (1990).PubMedGoogle Scholar
  6. [6]
    G. Schwarzenbach and H. Flaschka,Complexometric Titrations. Methuen, London 1969.Google Scholar
  7. [7]
    A. Ringbom,Complexation in Analytical Chemistry. Interscience, New York 1963.Google Scholar
  8. [8]
    The Merck Index 10th (1983) and earlier editions, Merck & Co., Inc, Rahway, N.J.Google Scholar
  9. [9]
    D. D. Perrin and B. Dempsey,Buffers for pH and Metal Ion Control, 1st edition, p. 176, Chapman and Hall, London, 1974.Google Scholar
  10. [10]
    L. G. Sillen and A. E. Martell,Stability Constants of Metal-Ion Complexes, Special Publication No 17 (1964) p. 754 and No 25 (1971) p. 865. The Chemical Society, London.Google Scholar
  11. [11]
    M. N. Hughes,The Inorganic Chemistry of Biological Processes, 2nd edition, pp. 55–60, 260, Wiley, New York 1972.Google Scholar
  12. [12]
    R. P. Agarwal and D. D. Perrin,Copper (II) and Zinc(II) complexes of glycylglycyl-l-chistidine and derivatives. J. Chem. Soc. Dalton Trans. 53–57 (1977).Google Scholar
  13. [13]
    S. Siggia (Ed.)Quantitative Organic Analysis via Functional Groups, 3rd edition, p. 39. Wiley, New York 1963.Google Scholar
  14. [14]
    A. S. Prasad InTrace Elements and Iron in Human Metabolism. (Ed. A. S. Prasad) p. 285, Plenum, New York 1978.Google Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • D. P. Fairlie
    • 1
  • M. W. Whitehouse
    • 1
  • R. M. Taylor
    • 2
  1. 1.Department of PathologyUniversity of AdelaideAdelaide
  2. 2.CSIRO Division of SoilsUrrbrae

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