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, Volume 36, Issue 1–2, pp 107–111 | Cite as

The selective protection afforded by ebselen against lipid peroxidation in an ROS-dependent model of inflammation

  • H. R. Griffiths
  • E. J. Dowling
  • T. Sahinoglu
  • D. R. Blake
  • M. Parnham
  • J. Lunec
Inflammation and Immunomodulation

Abstract

The effects of an experimental model of hydrogen-peroxide-induced foot pad oedema on indices of oxidative damage to biomolecules have been investigated. We have demonstrated increased levels of fluorescent protein and lipid peroxides occurring in plasma at 24 and 48 h post-injection. In addition, a decrease in the degree of galactosylation of IgG was observed which kinetically related the degree of inflammation and to the increase in protein autofluorescence (a specific index of oxidative damage).

The effects of ebselen, a novel organoselenium compound which protects against oxidative tissue injury in a glutathione-peroxidase-like manner, have also been examined in this model. Pretreatment of animals with a dose of 50 mg/kg ebselen afforded significant and selective protection against lipid peroxidation only. This effect may contribute to the anti-inflammatory effect of this agent in hydroperoxide-linked tissue damage.

Keywords

Lipid Peroxide Lipid Peroxidation Experimental Model Oxidative Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • H. R. Griffiths
    • 1
  • E. J. Dowling
    • 2
  • T. Sahinoglu
    • 2
  • D. R. Blake
    • 2
  • M. Parnham
    • 3
  • J. Lunec
    • 1
  1. 1.Molecular Toxicity Group, Clinical Sciences BlockGlenfield General HospitalLeicesterUK
  2. 2.Bone and Joint Research UnitThe London Hospital Medical CollegeLondonUK
  3. 3.A Nattermann & Cie, Pharmacology ResearchCologneGermany

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