The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells
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Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100 μM) potentiated IL-1 production (2–40 fold) and TNF production (2–18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.
KeywordsTumor Necrosis Tumor Necrosis Factor Mononuclear Cell Peripheral Blood Mononuclear Cell Healthy Donor
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