Abstract
The effect of two {ie29-2} agonists, salbutamol (100 μg/kg i.v.) and broxaterol (100 μg/kg i.v.), on airway microvascular leakage induced by vagal stimulation was studied in anaesthetised guinea pigs. Airway microvascular leakage was measured by Evans blue extravasation. Broxaterol, but not salbutamol, inhibited Evans blue dye extravasation at all airway levels, an effect prevented by pretreatment with propranolol (1 mg/kg). Neither of the {ie29-3} had any effect on substance P-induced Evans blue dye extravasation. Broxaterol inhibits the prejunctional release of tachykinins from airway sensory nerves by stimulation of β-receptors. The mechanism by which β-adrenoceptor agonists prevent airway microvascular leakage deserves further study.
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Hui, K.P., Ventresca, P., Brown, A.C. et al. Modulation of neurally mediated airway microvascular leakage in guinea-pig airways byβ 2 agonists. Agents and Actions 36, 29–32 (1992). https://doi.org/10.1007/BF01991224
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DOI: https://doi.org/10.1007/BF01991224