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Antioxidant and anti-inflammatory activities of selenomethylene blue

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Abstract

The selenium derivative of methylene blue, has been compared with the parent compound. Unlike some organic selenium compounds neither of the compounds affected macrophage chemiluminescence nor did they catalyse the glutathione-dependent breakdown of hydroperoxidesin vitro. However, both inhibited iron-induced hepatic lipid peroxidation,in vitro andex vivo, the selenium derivative being 3-fold more active in this respect. Both compounds inhibited inflammatory paw oedema in the rat, selenomethylene blue being the more active. Selenomethylene blue, thus, does not exhibit a different anti-oxidant/anti-inflammatory profile from that of the parent sulphur compound, but exhibits increased inhibitory activity.

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References

  1. S. O. Chung and S. Y. Nam,The radioprotective effect against gamma-irradiation of methylene blue in the rat with reference to serum enzymes and pancreatic protein fractions examined by isoelectric focusing. J. Radiat. Res.16, 211–223 (1975).

    PubMed  Google Scholar 

  2. J. H. Doroshow,Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones. Proc. Natl. Acad. Sci. USA83, 4514–4518 (1986).

    PubMed  Google Scholar 

  3. W. Martin, K. M. Drazan and A. C. Newby,Methylene blue but not changes in cyclic GMP inhibits resting and bradykinin-stimulated production of prostacyclin by pig aorta endothelial cells. Br. J. Pharmacol.97, 51–56 (1989).

    PubMed  Google Scholar 

  4. K. F. Swingle, R. L. Bell and G. G. I. Moore,Anti-inflammatory activity of antioxidants. InAnti-Inflammatory and Anti-Rheumatic Drugs, Vol. III (Ed. K. D. Rainsford) pp. 105–126, CRC Press, Boca Raton 1985.

    Google Scholar 

  5. G. Waschulzik, H. Oelschläger and H. Schuldes, Eur. Patent No 68425 (1985).

  6. S. Leyck, E. Etschenberg, U. Hadding and J. Winkelmann,A new model of acute inflammation: Cobra venom factor-induced paw oedema. Agents and Actions13, 437–438 (1983).

    Google Scholar 

  7. M. J. Parnham and E. Graf,Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem. Pharmacol.36, 3095–3102 (1987).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Rhône-Poulenc Rorer, P.O. Box 350120, D-5000, Cologne 30

    S. Leyck &  M. J. Parnham

  2. Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Georg-Voigt-Straße 14, D-6000, Frankfurt/Main, Germany

    H. Oelschläger

Authors
  1. S. Leyck
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  2. H. Oelschläger
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  3. M. J. Parnham
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Leyck, S., Oelschläger, H. & Parnham, M.J. Antioxidant and anti-inflammatory activities of selenomethylene blue. Agents and Actions 38 (Suppl 2), C143–C145 (1993). https://doi.org/10.1007/BF01991165

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  • DOI: https://doi.org/10.1007/BF01991165

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