Previous laboratory based in vestigations of a commercially prepared freeze-dried extract of the NZ green-lipped mussel (Perna canaliculus) showed that the material had the capacity to inhibit experimentally induced inflammation. The activity was thought to reside within an aqueous fraction containing high molecular weight material, possibly a polysaccharide. In the present study, a polysaccharide (glycogen) has been extracted fromPerna canaliculus and its anti-inflammatory activity examined in an attempt to characterise further the high molecular weight components of this mollusc. Glycogen extracts administered i.v. demonstrated a dose-dependent anti-inflammatory effect in rats with carrageenin-induced footpad oedema. Mobilisation of neutrophils to the site of an inflammatory stimulus was also significantly reduced. This activity was lost if the glycogen extract was treated with KOH or proteinase K, suggesting that the anti-inflammatory properties resided within a protein moiety associated with the glycogen.
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T. E. Miller and D. J. Ormrod, Theanti-inflammatory activity of Perna canaliculus (New Zealand green lipped mussel). NZ Med. J.92, 187–193 (1980).
R. G. Gibson, S. L. M. Gibson, V. Conway and D. Chappell,Perna canaliculus in the treatment of arthritis. Practioner224, 955 (1980).
R. A. F. Couch, D. J. Ormrod and T. E. Miller,Anti-inflammatory activity in fractionated extracts of the green-lipped mussel. NZ Med. J.95, 803–806 (1982).
S. Cawley, D. J. Ormrod and T. E. Miller,Immunopotentiation in infectious disease: effect of glucan and lentinan on host defences and experimental infections. Int. J. Immunother.3, 159–170 (1987).
J. Roesler, A. Emmendörffer, C. Steinmüller, B. Luettig, H. Wagner and M. L. Lohmann-Matthes,Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int. J. Immunopharmacol.13, 931–941 (1991).
D. J. Ormrod and T. E. Miller,Assessment of anti-inflammatory agents using 125 I labelled human serum albumin to quantify footpad edema volume in the rat. Pharm. Res.8, 1270–1273 (1991).
S. Cawley, D. J. Ormrod, J. W. Paxton and T. E. Miller,Sustained release of a corticosteroid using polymeric implants. Agents Actions19, 233–243 (1986).
T. E. Miller and H. Wu,In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. NZ Med. J.97, 355–357 (1984).
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Miller, T.E., Dodd, J., Ormrod, D.J. et al. Anti-inflammatory activity of glycogen extracted fromPerna canaliculus (NZ green-lipped mussel). Agents and Actions 38, C139–C142 (1993). https://doi.org/10.1007/BF01991164
- Molecular Weight
- High Molecular Weight
- Inflammatory Stimulus