Skip to main content

Anti-inflammatory activity of glycogen extracted fromPerna canaliculus (NZ green-lipped mussel)

Abstract

Previous laboratory based in vestigations of a commercially prepared freeze-dried extract of the NZ green-lipped mussel (Perna canaliculus) showed that the material had the capacity to inhibit experimentally induced inflammation. The activity was thought to reside within an aqueous fraction containing high molecular weight material, possibly a polysaccharide. In the present study, a polysaccharide (glycogen) has been extracted fromPerna canaliculus and its anti-inflammatory activity examined in an attempt to characterise further the high molecular weight components of this mollusc. Glycogen extracts administered i.v. demonstrated a dose-dependent anti-inflammatory effect in rats with carrageenin-induced footpad oedema. Mobilisation of neutrophils to the site of an inflammatory stimulus was also significantly reduced. This activity was lost if the glycogen extract was treated with KOH or proteinase K, suggesting that the anti-inflammatory properties resided within a protein moiety associated with the glycogen.

This is a preview of subscription content, access via your institution.

References

  1. [1]

    T. E. Miller and D. J. Ormrod, Theanti-inflammatory activity of Perna canaliculus (New Zealand green lipped mussel). NZ Med. J.92, 187–193 (1980).

    Google Scholar 

  2. [2]

    R. G. Gibson, S. L. M. Gibson, V. Conway and D. Chappell,Perna canaliculus in the treatment of arthritis. Practioner224, 955 (1980).

    Google Scholar 

  3. [3]

    R. A. F. Couch, D. J. Ormrod and T. E. Miller,Anti-inflammatory activity in fractionated extracts of the green-lipped mussel. NZ Med. J.95, 803–806 (1982).

    Google Scholar 

  4. [4]

    S. Cawley, D. J. Ormrod and T. E. Miller,Immunopotentiation in infectious disease: effect of glucan and lentinan on host defences and experimental infections. Int. J. Immunother.3, 159–170 (1987).

    Google Scholar 

  5. [5]

    J. Roesler, A. Emmendörffer, C. Steinmüller, B. Luettig, H. Wagner and M. L. Lohmann-Matthes,Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int. J. Immunopharmacol.13, 931–941 (1991).

    PubMed  Google Scholar 

  6. [6]

    D. J. Ormrod and T. E. Miller,Assessment of anti-inflammatory agents using 125 I labelled human serum albumin to quantify footpad edema volume in the rat. Pharm. Res.8, 1270–1273 (1991).

    PubMed  Google Scholar 

  7. [7]

    S. Cawley, D. J. Ormrod, J. W. Paxton and T. E. Miller,Sustained release of a corticosteroid using polymeric implants. Agents Actions19, 233–243 (1986).

    PubMed  Google Scholar 

  8. [8]

    T. E. Miller and H. Wu,In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. NZ Med. J.97, 355–357 (1984).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to T. E. Miller.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Miller, T.E., Dodd, J., Ormrod, D.J. et al. Anti-inflammatory activity of glycogen extracted fromPerna canaliculus (NZ green-lipped mussel). Agents and Actions 38, C139–C142 (1993). https://doi.org/10.1007/BF01991164

Download citation

Keywords

  • Molecular Weight
  • Polysaccharide
  • High Molecular Weight
  • Inflammatory Stimulus
  • Perna