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Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment

  • General Inflammation
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Abstract

Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxyeicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.

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Authors and Affiliations

  1. Department of Pharmacology, Erasmus University, P.O. Box 1738, 3000 DR, Rotterdam

    F. J. Zijlstra & A. P. M. van Dijk

  2. Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam

    I. C. van Riemsdijk-Overbeeke & J. H. P. Wilson

  3. Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands

    R. J. Th. Ouwendijk

Authors
  1. F. J. Zijlstra
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  2. A. P. M. van Dijk
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  3. R. J. Th. Ouwendijk
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  4. I. C. van Riemsdijk-Overbeeke
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  5. J. H. P. Wilson
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Zijlstra, F.J., van Dijk, A.P.M., Ouwendijk, R.J.T. et al. Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment. Agents and Actions 38 (Suppl 2), C122–C124 (1993). https://doi.org/10.1007/BF01991158

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  • DOI: https://doi.org/10.1007/BF01991158

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