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A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats

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Abstract

The total plasma 5-HT levels of adjuvant arthritic rats were increased in animals of both strains in comparison to healthy controls. The exception was day 1, when the 5-HT plasma level in arthritic Lewis rats was decreased by 77%, but only by 17% in Wistar rats. Treatment with the 5-HT2 receptor antagonist ritanserin caused a significant inhibition of macroscopic arthritis at day 14 in Lewis but not in Wistar rats. The total plasma 5-HT level was significantly decreased by the 5-HT2 antagonists in both strains at various times. 5-HT as an autacoid with effects on the T-lymphocytes and on delayed hypersensitivity reactions might be responsible, at least in part, for strain differences regarding the incidence of secondary lesions in rat adjuvant arthritis.

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References

  1. D. L. Wilhelm,Chemical mediators, In:The Inflammatory Process. Vol. 1. (Eds. B. W. Zweifach, L. Grant and R. T. McCluskey) pp. 251–301, Academic Press, New York and London 1973.

    Google Scholar 

  2. H. R. Bourne, L. M. Lichtenstein, K. L. Melmon, C. S. Henney, Y. Weinstein and G. M. Shearer,Modulation of inflammation and immunity by cyclic AMP. Science184, 19–28 (1974).

    PubMed  Google Scholar 

  3. I. Paegelow, M. Hagen and P. Lange,Serotonin as a modulator of the cell-mediated hypersensitivity. Agents Actions15, 63–64 (1989).

    Google Scholar 

  4. L. M. Petrovic, S. A. Lorens, M. George, T. Cabrera, B. H. Gordon, R. J. Handa, D. B. Campbell and J. Clancy, jr.,Subchronic d -fenfluramine treatment enhances the immunological competence of old Fischer 344 rats. In:Serotonin: Molecular Biology, Receptors and Functional Effects. (Eds. J. R. Fozard, P. R. Saxena) pp. 389–397, Birkhäuser, Basel 1991.

    Google Scholar 

  5. K. Hellstrand and S. Hermodsson,Enhancement of human natural killer cell cytotoxicity by serotonin: role of non-TICD 16 + NK cells, accessory monocytes and 5-HT 1A receptors. Cell. Immunol.127, 199–214 (1990).

    PubMed  Google Scholar 

  6. J.-C. Ameisen, R. Meade and P. W. Askenase,A new interpretation of the involvement of serotonin in delayed-type hypersensitivity. Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells. J. Immunol.142, 1371–1379 (1989).

    Google Scholar 

  7. J. Kheifets, T. Thieme, A. Mirkovich and N. Ackerman,The effects of histamine and serotonin on polymorphonuclear leukocyte accumulation in the rat. Eur. J. Pharmacol.128, 179–186 (1986).

    PubMed  Google Scholar 

  8. W. Ptak, G. P. Geba and P. W. Askenase,Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. J. Immunol.146, 3929–3936 (1991).

    PubMed  Google Scholar 

  9. A. Gryfe, P. M. Sanders and D. L. Gardner,The mast cell in early rat adjuvant arthritis. Ann. Rheum. Dis.30, 24–30 (1971).

    PubMed  Google Scholar 

  10. R. Hirschelmann, H. Bekemeier, J. Metzner, A.-J. Giessler and A. Stelzner,Beeinflussung der Adjuvansarthritis durch Carrageenin, Compound 48/80, Histamin-Serotonin-antagonisten, nichtsteroidale Antiphlogistika sowie Proteasenhemmstoffe und deren mögliche Bezienhungen zu Entzündungsmediatoren. Acta Biol. Med. German.34, 1397–1406 (1975).

    PubMed  Google Scholar 

  11. P. Nebinger and M. Koel,Automatic determination of serotonin in biological fluids by liquid chromatography. J. Chromat.427, 326–330 (1988).

    Google Scholar 

  12. F. Awouters, C. J. E. Niemegeers, A. A. H. P. Megens, T. F. Meert and P. A. J. Janssen,Pharmacological profile of ritanserin: A very specific central serotonin S 2 -antagonist. Drug Develop. Res.15, 61–73 (1988).

    Google Scholar 

  13. J. E. Leysen, J. Wynants, A. Eens and P. A. J. Janssen,Ketanserin reduces a particular monoamine pool in peripheral tissues. Mol. Pharmacol.35, 375–380 (1989).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut Pharmakologie, Fachbereich Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 15, PF 8, D-4010, Halle/Saale, Deutschland

    M. Pertsch, K. Krause & R. Hirschelmann

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  1. M. Pertsch
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  2. K. Krause
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  3. R. Hirschelmann
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Pertsch, M., Krause, K. & Hirschelmann, R. A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats. Agents and Actions 38 (Suppl 2), C98–C101 (1993). https://doi.org/10.1007/BF01991150

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