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The effects of immunomodulatory thymic and splenic peptides and cyclosporin A on antigen-induced arthritis in the rat

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Abstract

Long-term treatment with natural and synthetic thymic and splenic peptides as well as cyclosporin A inhibited the development of antigen-induced arthritis in rats. This was demonstrated by decreased joint swelling and reduced degree of macroscopically and histologically evaluated severity of synovitis. The drug treatment also decreased serum levels of antibodies against the specific antigen methylated bovine serum albumin (mBSA) and against cartilage proteoglycans and collagens type I and II.

The conclusion from these studies is that the treatment with immunomodulatory thymic and splenic peptides and with the T-cell-directed immunosuppressive drug cyclosporin A inhibits the specific immune response against mBSA and/or the development of autoimmunity against cartilage constituents. The decreased immune reactivity in the joint may reduces the severity of chronic joint inflammation.

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References

  1. D. C. Dumonde and L. E. Glynn,The production of arthritis in rabbits by an immunological reaction to fibrin. Br. J. Exp. Pathol.43, 373–383 (1962).

    PubMed  Google Scholar 

  2. D. Brackertz, G. F. Mitchell and I. R. Mackay,Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum.20, 841–850 (1977).

    PubMed  Google Scholar 

  3. R. J. Griffiths,Characterisation and pharmacological sensitivity of antigen arthritis induced by methylated bovine serum albumin in the rat. Agents and Actions35, 88–95 (1992).

    PubMed  Google Scholar 

  4. W. B. van den Berg, L. B. A. van de Putte, W. A. Zwarts and L. A. B. Joosten,Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J. Clin. Invest.74, 1850–1859 (1984).

    PubMed  Google Scholar 

  5. D. Brackertz, G. F. Mitchell, M. A. Vadas, I. R. Mackay and J. F. A. P. Miller,Studies on antigen-induced arthritis in mice. II. Immunologic correlates of arthritis susceptibility in mice. J. Immunol.118, 1639–1644 (1977).

    PubMed  Google Scholar 

  6. R. Bräuer, K. Thoss and G. Waldmann,Autoreactive T-helper cells in experimental arthritis. Agents and Actions32, 103–105 (1991).

    PubMed  Google Scholar 

  7. R. Bräuer, K. Thoss, S. Henzgen and G. Waldmann,Significance of cell-mediated and humoral immunity in the acute and chronic phase of antigen-induced arthritis in rabbits. Exp. Pathol.34, 197–208 (1988).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Pathology, Friedrich Schiller University, O-6900, Jena

    R. Bräuer, S. Henzgen, J. Kriegsmann & K. Thoss

  2. Dr. Mulli GmbH & Co. KG, W-7844, Neuenburg, Germany

    A. J. Egg

Authors
  1. R. Bräuer
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  2. A. J. Egg
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  3. S. Henzgen
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  4. J. Kriegsmann
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  5. K. Thoss
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Bräuer, R., Egg, A.J., Henzgen, S. et al. The effects of immunomodulatory thymic and splenic peptides and cyclosporin A on antigen-induced arthritis in the rat. Agents and Actions 38 (Suppl 2), C95–C97 (1993). https://doi.org/10.1007/BF01991149

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  • DOI: https://doi.org/10.1007/BF01991149

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