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, Volume 38, Supplement 2, pp C73–C76 | Cite as

Expression of mRNA for interleukin 6 by cells infiltrating epiretinal membranes in proliferative vitreoretinopathy

  • G. A. Limb
  • S. Kapur
  • H. Woon
  • W. A. Franks
  • S. E. Jones
  • A. H. Chignell
  • D. C. Dumonde
Future Trends in the Therapy of Inflammatory Disease

Abstract

We have investigated the expression of mRNA for interleukin 6 (IL-6) in cells infiltrating 12 epiretinal membranes, and the presence of biologically active IL-6 in vitreous humour available from five corresponding eyes. The results showed that nine of the 12 membranes (75%) contained cells expressing mRNA for this cytokine. Although in two of the specimens pigmented cells were identified as some of the cells expressing mRNA for IL-6, we did not identify the nature of IL-6 mRNA-producing cells infiltrating the membranes. Interestingly, two vitreous samples from eyes whose membranes did not contain cells with mRNA for IL-6 exhibited significant concentrations of IL-6 (315 and 28 μg/ml). Parallel study of mRNA for IL-6 in PVR biopsies and of IL-6 levels in corresponding vitreous may indicate how cytokine-mediated pathways of inflammation are involved in the pathogenesis of epiretinal membrane formation.

Keywords

Significant Concentration Parallel Study Pigment Cell Membrane Formation Vitreous Humour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1993

Authors and Affiliations

  • G. A. Limb
    • 1
  • S. Kapur
    • 1
  • H. Woon
    • 2
  • W. A. Franks
    • 2
  • S. E. Jones
    • 3
  • A. H. Chignell
    • 1
  • D. C. Dumonde
    • 1
  1. 1.Department of ImmunologyThe Rayne Institute St. Thomas' Hospital, UMDSLondon
  2. 2.Department of OphthalmologyThe Rayne Institute St. Thomas' Hospital, UMDSLondon
  3. 3.Department of PharmacologyThe Rayne Institute St. Thomas' Hospital, UMDSLondon

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