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Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat

  • Neurogenic Pain and Inflammation
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Abstract

Using a non-invasive laser Doppler velocimetry technique to measure skin blood flow in the rat skin, we have shown that chronic treatment with capsaicin inhibited the vasodilator response to a non-pathological, local heat (44°C, 20 min duration) stimulus. However, sympathectomy, accomplished with chronic treatment of guanethidine, had no effect on this heat-induced vasodilation. Topical steroids have also been shown to inhibit this response thus, since the heat-dilator response appears from these results to be brought about by the release of sensory neuropeptides, the sensory neuron may be a target for topical steroid action.

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, The William Harvey Research Institute, St. Bartholomew's Medical College, Charterhouse Square, ECIM 6BQ, London, UK

    A. Ahluwalia & R. J. Flower

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  1. A. Ahluwalia
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  2. R. J. Flower
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Ahluwalia, A., Flower, R.J. Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat. Agents and Actions 38 (Suppl 2), C16–C18 (1993). https://doi.org/10.1007/BF01991123

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  • DOI: https://doi.org/10.1007/BF01991123

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