Agents and Actions

, Volume 36, Supplement 1, pp C27–C31 | Cite as

Immunological aspects of inflammatory bowel diseases of the human gut

  • H. J. F. Hodgson
Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy New Approaches to Therapy of Gastrointestinal Inflammation


The gut has a highly specialized immune apparatus, particularly involving the production of protective secretory immunoglobulin A (IgA), but also involving T-cell immunity. Secretory IgA plays a major role in preventing antigen uptake, both of infectious and non-infectious types. IgA immune responses are initiated by antigen uptake into specialized lymphoid aggregates such as Peyer's patches, and IgA plasma cell precursors are subsequently distributed throughout the gut and also over other mucosal surfaces.

The clinical consequences of perturbation of the local immune system of the gut are surveyed in this article, including the consequences of immunodeficiency and the conditions reflecting an enhanced expression of immunity in the gut mucosa. The potential impact of non-steroidal anti-inflammatory drugs on the local immune system is discussed.


Inflammatory Bowel Disease Plasma Cell Cell Precursor Mucosal Surface Lymphoid Aggregate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. [1]
    T. B. Tomasi, E. M. Tan, A. Soloman et al.,Characteristics of an immune system common to certain external secretions. J. Exp. Med.121, 101–124 (1965).CrossRefPubMedGoogle Scholar
  2. [2]
    J. Mestecky and J. R. McGhee,Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol.40, 153–245 (1987).PubMedGoogle Scholar
  3. [3]
    H. C. Thomas and D. M. V. Parrot,The induction of tolerance to a soluble protein antigen by oral administration. Immunology27, 631 (1974).PubMedGoogle Scholar
  4. [4]
    R. L. Owen and A. L. Jones,Epithelial cell specialization with human Peyer's patches. Gastroenterology66, 189 (1974).PubMedGoogle Scholar
  5. [5]
    D. R. Green and S. S. Martin,Suppression and contrasuppression in the regulation of gut-associated immune responses. Ann. New York Acad. Sci.409, 284 (1983).Google Scholar
  6. [6]
    J. Bienenstock,Gut and bronchus-associated lymphoid tissue: An overview. Adv. Exp. Med.149, 417–477 (1982).Google Scholar
  7. [7]
    P. Brandtzaeg,Immunohistochemical characterization of intracellular J chain and binding site for secretory component (SC) in the human immunoglobulin (Ig)-producing cells. Mol. Immunol.20, 941–966 (1983).CrossRefPubMedGoogle Scholar
  8. [8]
    W. R. Brown, R. W. Newcombe and K. Ishizaka,Proteolytic degradation of exocrine and serum immunoglobulins. J. Clin. Invest.49, 1374–1380 (1970).PubMedGoogle Scholar
  9. [9]
    D. L. Delacroix, H. J. F. Hodgson, A. McPherson et al.,Selective transport of polymeric immunoglobulin A in bile. J. Clin. Invest.70, 230–241 (1982).PubMedGoogle Scholar
  10. [10]
    A. D. B. Webster,Giardiasis and immunodeficiency diseases. Transactions of the Royal Society of Tropical Medicine and Hygiene74, 440–443 (1980).CrossRefPubMedGoogle Scholar
  11. [11]
    G. L. Asherson and A. D. B. Webster,Diagnosis and treatment of immunodeficiency diseases. Blackwell Scientific Publications, Oxford 1980.Google Scholar
  12. [12]
    J. Weicker and B. J. Underdown,A study of the association of human secretory component with IgA and IgM proteins. J. Immunol.114, 265–269 (1975).PubMedGoogle Scholar
  13. [13]
    P. Brandtzaeg, K. Valnes, H. Scott et al.,The human gastrointestinal secretory immune system in health and disease. Scand. J. Gastroenterol.20(114, 17–83 (1985).Google Scholar
  14. [14]
    A. Ferguson and D. M. V. Parrott,Histopathology and the cause of rejection of allografts of mouse small intestine. Transplantation15, 546–554 (1973).PubMedGoogle Scholar
  15. [15]
    H. J. F. Hodgson and D. Jewell,Immunology of inflammatory bowel disease. InGastrointestinal and Liver Immunology. Bailliere Tindall Vol. 1. (Eds. R. Wright and H. J. F. Hodgson) pp. 531–546.Google Scholar
  16. [16]
    F. J. Dixon, J. J. Vazquez, W. O. Weigle and C. G. Cochrane,Pathogenesis of serum sickness. Arch. Pathol.65, 18–28 (1958).Google Scholar
  17. [17]
    A. S. Mee, J. E. McLaughlin, H. J. F. Hodgson and D. P. Jewell,Chronic immune colitis in rabbits. Gut20, 1–5 (1979b).PubMedGoogle Scholar
  18. [18]
    C. A. Dinarello,Biology of interleukin 1. FASEB J.2, 108–115 (1988).PubMedGoogle Scholar
  19. [19]
    T. Kishimoto,The biology of interleukin 6. Blood74, 1–10 (1989).PubMedGoogle Scholar
  20. [20]
    B. Bentler and C. Carami,The biology of TNF — A primary mediator of the host response. Ann. Rev. Immunol.7, 625–655 (1989).Google Scholar
  21. [21]
    M. Ligumsky, F. Karmeli, P. Sharon et al.,Enhanced thromboxane A 2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine. Gastroenterology81, 444–449 (1981).PubMedGoogle Scholar
  22. [22]
    I. Bjarnason,NSAID-induced small intestinal inflammation in man. InRecent Advances in Gastroenterology. (Ed. R. E. Pounder) pp. 23–46. Churchill Livingstone, London 1988.Google Scholar
  23. [23]
    S. Levi, R. A. Goodlad, C. Y. Lee et al.,NSAIDs inhibit the processes of gastric mucosal repair which lead to healing of gastric ulcer. Lancet336, 840–843 (1990).CrossRefPubMedGoogle Scholar
  24. [24]
    D. S. Rampton and G. E. Sladen,Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment. Prostaglandins21, 417–425 (1981).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • H. J. F. Hodgson
    • 1
  1. 1.Department of Medicine, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK

Personalised recommendations